GZF1 - GDNF inducible zinc finger protein 1 Gene

Also Known as JLSM; ZBTB23; ZNF336

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64412

About GZF1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,361,127-23,373,062 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues, 51 paralogues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 10.9), bone marrow (RPKM 10.5) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GZF1 Products (3)

mRNA Protein Name
NM_001317012.2 NP_001303941.1 GDNF-inducible zinc finger protein 1 isoform a
NM_001317019.1 NP_001303948.1 GDNF-inducible zinc finger protein 1 isoform b
NM_022482.5 NP_071927.1 GDNF-inducible zinc finger protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16049025 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
16049025 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16049025 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
16049025 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16049025 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16049025 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16049025 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16049025 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GZF1 Protein Structure

BTB

BTB: BTB/POZ domain (21 - 130)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (317 - 340)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (348 - 371)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (377 - 400)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (407 - 414)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (421 - 445)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (449 - 473)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (478 - 502)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (506 - 529)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (533 - 557)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (561 - 585)

  • 0
  • 200
  • 400
  • 600
  • 711 a.a.
Protein Preferred Names Protein Names

GDNF-inducible zinc finger protein 1

  • zinc finger and BTB domain-containing protein 23

Related Diseases

Diseases Alias
Joint Laxity, Short Stature, And Myopia

  • JLSM

  • Severe Myopia-Generalized Joint Laxity-Short Stature Syndrome
Pectus Carinatum

  • Carinatum Deformity Of The Chest
Larsen Syndrome

  • LRS

  • Larsen Syndrome, Dominant Type

  • Dominant Larsen Syndrome

  • Autosomal Dominant Larsen Syndrome

  • Larsens Syndrome
Acute Salpingitis
Glycogen Storage Disease Ix
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05938 GZF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GZF1 VGNC VGNC:62744
Rattus norvegicus GZF1 RGD RGD:1562321
Canis familiaris GZF1 VGNC VGNC:41576
Macaca mulatta GZF1 VGNC VGNC:73173
Bos taurus GZF1 VGNC VGNC:29732
Mus musculus GZF1 MGD MGI:1921783
Others GZF1 NCBI