PIRT - phosphoinositide interacting regulator of transient receptor potential channels Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 644139

About PIRT

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:10,822,470-10,838,087 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 1 paralogue. Biased expression in adrenal (RPKM 1.6), brain (RPKM 1.3) and 7 other tissues.

Summary

Predicted to enable phosphatidylinositol bisphosphate binding activity and transmembrane transporter binding activity. Predicted to be involved in phosphatidylinositol-mediated signaling and positive regulation of cation channel activity. Predicted to act upstream of or within behavioral response to pain and response to heat. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PIRT Products (1)

mRNA Protein Name
NM_001101387.2 NP_001094857.1 phosphoinositide-interacting protein

PIRT Protein Structure

PIRT

PIRT: Phosphoinositide-interacting protein family (5 - 136)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

phosphoinositide-interacting protein

  • phosphoinositide-interacting regulator of TRPV1

Related Diseases

Diseases Alias
Spastic Paraplegia 50, Autosomal Recessive

  • Hereditary Spastic Paraplegia 50

  • SPG50

  • Ap-4 Deficiency Syndrome

  • Ap-4-Associated Hereditary Spastic Paraplegia

  • Adaptor Protein Complex 4 Deficiency

  • Cerebral Palsy, Spastic Quadriplegic, 3, Formerly

  • Cpsq3, Formerly

  • Autosomal Recessive Spastic Paraplegia 50

  • Cpsq3

  • Spastic Quadriplegic Cerebral Palsy 3

  • Ap-4 Deficiency

  • Ap-4-Associated Hsp

  • Paraplegia, Spastic, Autosomal Recessive, Type 50

  • Spastic Paraplegia-50, Autosomal Recessive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10572 PIRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIRT MGD MGI:2443635
Bos taurus PIRT VGNC VGNC:32916
Canis familiaris PIRT VGNC VGNC:44580
Felis catus PIRT VGNC VGNC:99318
Rattus norvegicus PIRT RGD RGD:1565284
Others PIRT NCBI