2. Gene
  3. CIAO3 - cytosolic iron-sulfur assembly component 3 Gene

CIAO3 - cytosolic iron-sulfur assembly component 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PRN; HPRN; IOP1; NAR1; LET1L; NARFL

Gene ID: 64428 | Gene type: protein coding

About CIAO3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:729,765-740,997 (from NCBI)

This gene has 21 transcripts (splice variants), 93 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 7.4), prostate (RPKM 7.1) and 25 other tissues.

Summary

Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in several processes, including iron-sulfur cluster assembly; oxygen homeostasis; and response to hypoxia. Part of CIA complex. [provided by Alliance of Genome Resources, Apr 2022]

CIAO3 Products(2)

mRNA Protein Name
NM_001304799.2 NP_001291728.1 cytosolic iron-sulfur assembly component 3 isoform 2
NM_022493.3 NP_071938.1 cytosolic iron-sulfur assembly component 3 isoform 1

CIAO3 Protein Structure

Fe_hyd_lg_C

Fe_hyd_lg_C: Iron only hydrogenase large subunit, C-terminal domain (111 - 406)

Fe_hyd_SSU

Fe_hyd_SSU: Iron hydrogenase small subunit (415 - 465)

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  • 476 a.a.
Protein Preferred Names Protein Names

cytosolic iron-sulfur assembly component 3

LET1 like/JFP15

Related Diseases

Diseases Alias
Acute Serous Otitis Media

Acute Non-Suppurative Otitis Media - Serous

Acute Transudative Otitis Media
Non-Suppurative Otitis Media

Nonsuppurative Otitis Media
Autoimmune Peripheral Neuropathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02703 CIAO3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CIAO3 VGNC VGNC:58596
Rattus norvegicus CIAO3 RGD RGD:1305982
Macaca mulatta CIAO3 VGNC VGNC:70948
Mus musculus CIAO3 MGD MGI:1914813
Felis catus CIAO3 VGNC VGNC:60896
Canis familiaris CIAO3 VGNC VGNC:54047