CIAO3 - cytosolic iron-sulfur assembly component 3 Gene

Also Known as PRN; HPRN; IOP1; NAR1; LET1L; NARFL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64428

About CIAO3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:729,765-740,997 (from NCBI)

This gene has 21 transcripts (splice variants), 93 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 7.4), prostate (RPKM 7.1) and 25 other tissues.

Summary

Predicted to enable 4 iron, 4 sulfur cluster binding activity. Involved in several processes, including iron-sulfur cluster assembly; oxygen homeostasis; and response to hypoxia. Part of CIA complex. [provided by Alliance of Genome Resources, Apr 2022]

CIAO3 Products (2)

mRNA Protein Name
NM_001304799.2 NP_001291728.1 cytosolic iron-sulfur assembly component 3 isoform 2
NM_022493.3 NP_071938.1 cytosolic iron-sulfur assembly component 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23585563 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular oxygen homeostasis IDA
IDA: Inferred from direct assay
16956324 GOA
involved in iron-sulfur cluster assembly IMP
IMP: Inferred from mutant phenotype
18270200 GOA
involved in regulation of gene expression IDA
IDA: Inferred from direct assay
16956324 GOA
involved in response to hypoxia IDA
IDA: Inferred from direct assay
16956324 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic [4Fe-4S] assembly targeting complex IDA
IDA: Inferred from direct assay
22678361 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIAO3 Protein Structure

Fe_hyd_lg_C

Fe_hyd_lg_C: Iron only hydrogenase large subunit, C-terminal domain (111 - 406)

Fe_hyd_SSU

Fe_hyd_SSU: Iron hydrogenase small subunit (415 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

cytosolic iron-sulfur assembly component 3

  • LET1 like/JFP15

Related Diseases

Diseases Alias
Acute Serous Otitis Media

  • Acute Non-Suppurative Otitis Media - Serous

  • Acute Transudative Otitis Media
Non-Suppurative Otitis Media

  • Nonsuppurative Otitis Media
Autoimmune Peripheral Neuropathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02703 CIAO3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CIAO3 VGNC VGNC:58596
Rattus norvegicus CIAO3 RGD RGD:1305982
Macaca mulatta CIAO3 VGNC VGNC:70948
Mus musculus CIAO3 MGD MGI:1914813
Felis catus CIAO3 VGNC VGNC:60896
Canis familiaris CIAO3 VGNC VGNC:54047
Others CIAO3 NCBI