NDST4 - N-deacetylase and N-sulfotransferase 4 Gene

Also Known as N-HSST; NDST-4; NHSST4; N-HSST 4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64579

About NDST4

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:114,827,763-115,113,620 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

NDST4 Products (1)

mRNA Protein Name
NM_022569.3 NP_072091.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

NDST4 Protein Structure

HSNSD

HSNSD: heparan sulfate-N-deacetylase (20 - 505)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (595 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 872 a.a.
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

  • N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4

Related Diseases

Diseases Alias
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09121 NDST4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22675 Ndst4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29189 Ndst4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDST4 VGNC VGNC:78530
Mus musculus NDST4 MGD MGI:1932545
Macaca mulatta NDST4 VGNC VGNC:100253
Rattus norvegicus NDST4 RGD RGD:1306531
Canis familiaris NDST4 VGNC VGNC:43684
Bos taurus NDST4 VGNC VGNC:31943
Others NDST4 NCBI