2. Gene
  3. NDST4 - N-deacetylase and N-sulfotransferase 4 Gene

NDST4 - N-deacetylase and N-sulfotransferase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as N-HSST; NDST-4; NHSST4; N-HSST 4

Gene ID: 64579 | Gene type: protein coding

About NDST4

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:114,827,763-115,113,620 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

NDST4 Products(1)

mRNA Protein Name
NM_022569.3 NP_072091.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

NDST4 Protein Structure

HSNSD

HSNSD: heparan sulfate-N-deacetylase (20 - 505)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (595 - 844)

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  • 872 a.a.
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4

Related Diseases

Diseases Alias
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09121 NDST4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDST4 VGNC VGNC:78530
Mus musculus NDST4 MGD MGI:1932545
Macaca mulatta NDST4 VGNC VGNC:100253
Rattus norvegicus NDST4 RGD RGD:1306531
Canis familiaris NDST4 VGNC VGNC:43684
Bos taurus NDST4 VGNC VGNC:31943