GPR135 - G protein-coupled receptor 135 Gene

Also Known as HUMNPIIY20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64582

About GPR135

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,452,783-59,465,380 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 3 paralogues. Broad expression in testis (RPKM 3.7), ovary (RPKM 1.1) and 20 other tissues.

Summary

Enables Arrestin family protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR135 Products (1)

mRNA Protein Name
NM_022571.6 NP_072093.2 G-protein coupled receptor 135

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arrestin family protein binding IDA
IDA: Inferred from direct assay
28827538 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28827538 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
28827538 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28827538 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR135 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (120 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 135

  • probable G-protein coupled receptor 135

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05657 GPR135 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GPR135 VGNC VGNC:29549
Mus musculus GPR135 MGD MGI:2676315
Rattus norvegicus GPR135 RGD RGD:727844
Felis catus GPR135 VGNC VGNC:104395
Others GPR135 NCBI