PARP12 - poly(ADP-ribose) polymerase family member 12 Gene

Also Known as ZC3H1; ARTD12; MST109; MSTP109; ZC3HDC1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64761

About PARP12

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,023,749-140,062,951 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 11.7), small intestine (RPKM 11.3) and 25 other tissues.

Summary

Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PARP12 Products (1)

mRNA Protein Name
NM_022750.4 NP_073587.1 protein mono-ADP-ribosyltransferase PARP12

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: Inferred from direct assay
25043379 GOA
Biological Process GO Annotation Evidence References Source
involved in protein auto-ADP-ribosylation IDA
IDA: Inferred from direct assay
25043379 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP12 Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (180 - 200)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (499 - 678)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP12

  • ADP-ribosyltransferase diphtheria toxin-like 12

Related Diseases

Diseases Alias
Osebold-Remondini Syndrome

  • Brachydactyly Type A6

  • Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

  • Bda6

  • Brachydactyly, Type A6
Osteogenesis Imperfecta, Type Xx

  • OI20

  • Osteogenesis Imperfecta Type 20

  • Osteogenesis Imperfecta, Type 20

  • Osteogenesis Imperfecta Type Xx

  • Osteogenesis Imperfecta 20
Intellectual Developmental Disorder, Autosomal Dominant 22

  • MRD22

  • Mental Retardation, Autosomal Dominant 22

  • Autosomal Dominant Non-Syndromic Intellectual Disability 22

  • Distal Monosomy 1q

  • Autosomal Dominant Intellectual Developmental Disorder 22

  • Autosomal Dominant Mental Retardation 22

  • Distal Deletion 1q

  • Monosomy 1qter

  • Telomeric Deletion 1q

  • Mental Retardation, Autosomal Dominant, Type 22
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PARP12 RGD RGD:1308628
Macaca mulatta PARP12 VGNC VGNC:81734
Mus musculus PARP12 MGD MGI:2143990
Felis catus PARP12 VGNC VGNC:80646
Canis familiaris PARP12 VGNC VGNC:51818
Bos taurus PARP12 VGNC VGNC:107230
Others PARP12 NCBI