2. Gene
  3. PARP12 - poly(ADP-ribose) polymerase family member 12 Gene

PARP12 - poly(ADP-ribose) polymerase family member 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZC3H1; ARTD12; MST109; MSTP109; ZC3HDC1

Gene ID: 64761 | Gene type: protein coding

About PARP12

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,023,749-140,062,951 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues and 8 paralogues. Ubiquitous expression in duodenum (RPKM 11.7), small intestine (RPKM 11.3) and 25 other tissues.

Summary

Enables protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PARP12 Products(1)

mRNA Protein Name
NM_022750.4 NP_073587.1 protein mono-ADP-ribosyltransferase PARP12

PARP12 Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (180 - 200)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (499 - 678)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP12

ADP-ribosyltransferase diphtheria toxin-like 12

Related Diseases

Diseases Alias
Osebold-Remondini Syndrome

Brachydactyly Type A6

Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities

Bda6

Brachydactyly, Type A6
Osteogenesis Imperfecta, Type Xx

OI20

Osteogenesis Imperfecta Type 20

Osteogenesis Imperfecta, Type 20

Osteogenesis Imperfecta Type Xx

Osteogenesis Imperfecta 20
Intellectual Developmental Disorder, Autosomal Dominant 22

MRD22

Mental Retardation, Autosomal Dominant 22

Autosomal Dominant Non-Syndromic Intellectual Disability 22

Distal Monosomy 1q

Autosomal Dominant Intellectual Developmental Disorder 22

Autosomal Dominant Mental Retardation 22

Distal Deletion 1q

Monosomy 1qter

Telomeric Deletion 1q

Mental Retardation, Autosomal Dominant, Type 22
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148754 PARP10-IN-3 Inhibitor 98.89% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.02% Unkown
HY-155993 YCH1899 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PARP12 RGD RGD:1308628
Macaca mulatta PARP12 VGNC VGNC:81734
Mus musculus PARP12 MGD MGI:2143990
Felis catus PARP12 VGNC VGNC:80646
Canis familiaris PARP12 VGNC VGNC:51818
Bos taurus PARP12 VGNC VGNC:107230