ENGASE - endo-beta-N-acetylglucosaminidase Gene

Homo sapiens

Gene ID: 64772 | Gene type: protein coding

About ENGASE

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,074,824-79,088,599 (from NCBI)

This gene has 10 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in spleen (RPKM 23.3), duodenum (RPKM 12.9) and 24 other tissues.

Summary

This gene encodes a cytosolic Enzyme which catalyzes the hydrolysis of Peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]

ENGASE Products(5)

mRNA	Protein	Name
NM_001042573.3	NP_001036038.1	cytosolic endo-beta-N-acetylglucosaminidase isoform 4
NM_001396052.1	NP_001382981.1	cytosolic endo-beta-N-acetylglucosaminidase isoform 1
NM_001396053.1	NP_001382982.1	cytosolic endo-beta-N-acetylglucosaminidase isoform 2
NM_001396054.1	NP_001382983.1	cytosolic endo-beta-N-acetylglucosaminidase isoform 3
NM_001396055.1	NP_001382984.1	cytosolic endo-beta-N-acetylglucosaminidase isoform 5

ENGASE Protein Structure

Glyco_hydro_85

0
200
400
600
743 a.a.

Protein Preferred Names

Protein Names

cytosolic endo-beta-N-acetylglucosaminidase

Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase

Related Diseases

Diseases

Alias

Ngly1-Deficiency

Deficiency Of N-Glycanase 1	Ngly1-Cddg
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome	Ngly1 Deficiency
Congenital Disorder Of Deglycosylation	Congenital Disorder Of Glycosylation Type Iv
Congenital Disorder Of Deglycosylation	Cddg
Congenital Disorder Of Glycosylation Type Iv	Cdg1v

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2999	Endo-β-N-acetylglucosaminidase		/	Unkown
HY-RS04375	ENGASE Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ENGASE	VGNC	VGNC:40363
Felis catus	ENGASE	VGNC	VGNC:61862
Mus musculus	ENGASE	MGD	MGI:2443788
Macaca mulatta	ENGASE	VGNC	VGNC:72099
Bos taurus	ENGASE	VGNC	VGNC:28493
Rattus norvegicus	ENGASE	RGD	RGD:1310868

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