ISL2 - ISL LIM homeobox 2 Gene

Homo sapiens

Gene ID: 64843 | Gene type: protein coding

About ISL2

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,336,773-76,342,475 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ISL2 Products(1)

mRNA	Protein	Name
NM_145805.3	NP_665804.1	insulin gene enhancer protein ISL-2

ISL2 Protein Structure

LIM

Homeobox

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

insulin gene enhancer protein ISL-2

ISL2 transcription factor, LIM/homeodomain, (islet-2)

Related Diseases

Diseases

Alias

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06932	ISL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ISL2	VGNC	VGNC:62975
Rattus norvegicus	ISL2	RGD	RGD:621849
Macaca mulatta	ISL2	VGNC	VGNC:108307
Mus musculus	ISL2	MGD	MGI:109156
Bos taurus	ISL2	VGNC	VGNC:30297