ISL2 - ISL LIM homeobox 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64843

About ISL2

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,336,773-76,342,475 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ISL2 Products (1)

mRNA Protein Name
NM_145805.3 NP_665804.1 insulin gene enhancer protein ISL-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27820671 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISL2 Protein Structure

LIM

LIM: LIM domain (27 - 85)

LIM

LIM: LIM domain (89 - 143)

Homeobox

Homeobox: Homeobox domain (193 - 248)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

insulin gene enhancer protein ISL-2

  • ISL2 transcription factor, LIM/homeodomain, (islet-2)

Related Diseases

Diseases Alias
Amme Complex

  • Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis

  • ATS-MR

  • Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome

  • Chromosome Xq22.3 Telomeric Deletion Syndrome

  • Amme Syndrome

  • Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06932 ISL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ISL2 VGNC VGNC:62975
Rattus norvegicus ISL2 RGD RGD:621849
Macaca mulatta ISL2 VGNC VGNC:108307
Mus musculus ISL2 MGD MGI:109156
Bos taurus ISL2 VGNC VGNC:30297
Others ISL2 NCBI