Nolc1 - nucleolar and coiled-body phosphoprotein 1 Gene

Also Known as Nopp140

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64896

Summary

Enables several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Involved in several processes, including box H/ACA RNA metabolic process; positive regulation of transcription, DNA-templated; and regulation of protein import into nucleus. Located in nucleolus and nucleoplasm. Part of box C/D RNP complex and box H/ACA snoRNP complex. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nolc1 Products (1)

mRNA Protein Name
NM_022869.2 NP_074060.2 nucleolar and coiled-body phosphoprotein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables TFIIB-class transcription factor binding IDA
IDA: Inferred from direct assay
8972203 RGD
enables box C/D methylation guide snoRNP complex binding IDA
IDA: Inferred from direct assay
10679015 RGD
enables box C/D sno(s)RNA binding IDA
IDA: Inferred from direct assay
10679015 RGD
enables box H/ACA snoRNA binding IDA
IDA: Inferred from direct assay
10679015 RGD
enables box H/ACA snoRNP complex binding IDA
IDA: Inferred from direct assay
10679015 RGD
enables nuclear localization sequence binding IDA
IDA: Inferred from direct assay
1623516 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12446766 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
9553145 RGD
Biological Process GO Annotation Evidence References Source
involved in box H/ACA sno(s)RNA metabolic process IGI
IGI: Inferred from genetic interaction
12700234 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8972203 RGD
involved in positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
12700234 RGD
involved in regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
1623516 RGD
Cellular Component GO Annotation Evidence References Source
part of box C/D methylation guide snoRNP complex IDA
IDA: Inferred from direct assay
10679015 RGD
part of box H/ACA snoRNP complex IDA
IDA: Inferred from direct assay
10679015 RGD
located in nucleolus IDA
IDA: Inferred from direct assay
10679015 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
1623516 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolar and coiled-body phosphoprotein 1

  • 140 kDa nucleolar phosphoprotein

  • nucleolar 130 kDa protein

  • nucleolar phosphoprotein 140

  • nucleolar phosphoprotein p130

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09420 NOLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nolc1 NCBI NCBI:9221