Nolc1 - nucleolar and coiled-body phosphoprotein 1 Gene

Rattus norvegicus

Also known as Nopp140

Gene ID: 64896 | Gene type: protein coding

About Nolc1

Summary

Enables several functions, including TFIIB-class transcription factor binding activity; snoRNA binding activity; and snoRNP binding activity. Involved in several processes, including box H/ACA RNA metabolic process; positive regulation of transcription, DNA-templated; and regulation of protein import into nucleus. Located in nucleolus and nucleoplasm. Part of box C/D RNP complex and box H/ACA snoRNP complex. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nolc1 Products(1)

mRNA	Protein	Name
NM_022869.2	NP_074060.2	nucleolar and coiled-body phosphoprotein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables TFIIB-class transcription factor binding	IDA IDA: Inferred from direct assay	8972203	RGD
enables box C/D methylation guide snoRNP complex binding	IDA IDA: Inferred from direct assay	10679015	RGD
enables box C/D sno(s)RNA binding	IDA IDA: Inferred from direct assay	10679015	RGD
enables box H/ACA snoRNA binding	IDA IDA: Inferred from direct assay	10679015	RGD
enables box H/ACA snoRNP complex binding	IDA IDA: Inferred from direct assay	10679015	RGD
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	1623516	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12446766	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9553145	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in box H/ACA sno(s)RNA metabolic process	IGI IGI: Inferred from genetic interaction	12700234	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8972203	RGD
involved in positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	12700234	RGD
involved in regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	1623516	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of box C/D methylation guide snoRNP complex	IDA IDA: Inferred from direct assay	10679015	RGD
part of box H/ACA snoRNP complex	IDA IDA: Inferred from direct assay	10679015	RGD
located in nucleolus	IDA IDA: Inferred from direct assay	10679015	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	1623516	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleolar and coiled-body phosphoprotein 1

140 kDa nucleolar phosphoprotein	nucleolar 130 kDa protein
nucleolar phosphoprotein 140	nucleolar phosphoprotein p130

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09420	NOLC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nolc1	NCBI	NCBI:9221

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