SKIC2 - SKI2 subunit of superkiller complex Gene

Also Known as HLP; 170A; SKI2; DDX13; SKI2W; SKIV2; THES2; SKIV2L; SKIV2L1

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 6499

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in Antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

SKIC2 Products (1)

mRNA Protein Name
XM_054356240.1 XP_054212215.1 superkiller complex protein 2 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' RNA helicase activity IDA
IDA: Inferred from direct assay
35120588 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IDA
IDA: Inferred from direct assay
32006463 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
32006463 GOA
Cellular Component GO Annotation Evidence References Source
part of Ski complex IDA
IDA: Inferred from direct assay
16024656 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

superkiller complex protein 2

  • SKI2 homolog, superkiller viralicidic activity 2-like

  • SKI2 subunit of superkiller complex protein

  • Ski2 like RNA helicase

  • helicase SKI2W

  • helicase-like protein

  • superkiller viralicidic activity 2-like