SLC26A6 - solute carrier family 26 member 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65010

About SLC26A6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,625,723-48,635,461 (from NCBI)

This gene has 22 transcripts (splice variants), 354 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 11.7), bone marrow (RPKM 8.2) and 25 other tissues.

Summary

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

SLC26A6 Products (6)

mRNA	Protein	Name
NM_001040454.1	NP_001035544.1	solute carrier family 26 member 6 isoform 4
NM_001281732.2	NP_001268661.1	solute carrier family 26 member 6 isoform 5
NM_001281733.2	NP_001268662.1	solute carrier family 26 member 6 isoform 6
NM_022911.3	NP_075062.2	solute carrier family 26 member 6 isoform 1
NM_134263.3	NP_599025.2	solute carrier family 26 member 6 isoform 2
NM_134426.3	NP_602298.2	solute carrier family 26 member 6 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables bicarbonate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12444019	GOA
enables chloride transmembrane transporter activity	IDA IDA: Inferred from direct assay	12444019	GOA
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	12444019	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12444019	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	15548529	GOA
enables solute:inorganic anion antiporter activity	IMP IMP: Inferred from mutant phenotype	20501439	GOA
enables sulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12444019	GOA
enables sulfate:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	12444019	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiotensin-activated signaling pathway	IDA IDA: Inferred from direct assay	15990874	GOA
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	15990874	GOA
involved in bicarbonate transport	IMP IMP: Inferred from mutant phenotype	20501439	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	18655181	GOA
involved in chloride transport	IDA IDA: Inferred from direct assay	15990874	GOA
involved in chloride transport	IMP IMP: Inferred from mutant phenotype	20501439	GOA
involved in oxalate transport	IMP IMP: Inferred from mutant phenotype	20501439	GOA
involved in protein kinase C signaling	IDA IDA: Inferred from direct assay	15990874	GOA
involved in regulation of intracellular pH	IDA IDA: Inferred from direct assay	15990874	GOA
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	20501439	GOA
involved in sulfate transmembrane transport	IMP IMP: Inferred from mutant phenotype	20501439	GOA
involved in transepithelial chloride transport	IMP IMP: Inferred from mutant phenotype	20501439	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11087667	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11087667	GOA
located in brush border membrane	IDA IDA: Inferred from direct assay	11087667	GOA
located in membrane	IDA IDA: Inferred from direct assay	11087667	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12444019	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A6 Protein Structure

Sulfate_transp

STAS

0
200
400
600
759 a.a.

Protein Preferred Names	Protein Names
solute carrier family 26 member 6	anion exchange transporter

Related Diseases

Diseases	Alias
Urolithiasis
Spermatocele
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Renal Tuberculosis	Tuberculosis, Renal Tuberculosis Of Kidney Tuberculosis Renal
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Diarrhea 1, Secretory Chloride, Congenital	DIAR1 Chloride Diarrhea, Congenital, Finnish Type Congenital Secretory Chloride Diarrhea 1 Congenital Chloride Diarrhea Finnish Type Congenital Chloride Diarrhea Chloridorrhea, Congenital Congenital Chloride Diarrhoea Finnish Type Congenital Chloridorrhea Congenital Secretory Chloride Diarrhoea 1 Chloridorrhea Congenital Cld Diarrhea 1 Secretory Chloride Congenital Diarrhea, Type 1, Chloride, Secretory, Congenital
Lower Urinary Tract Calculus	Calculus Of Lower Urinary Tract
Motility-Related Diarrhea
Urogenital Tuberculosis	Tuberculosis, Urogenital Genitourinary Tuberculosis
Bladder Calculus	Urinary Bladder Calculi Urinary Bladder Stone Bladder Calculi Bladder Stone Urinary Bladder Calculus Vesical Calculi Vesical Calculus Vesicolithiasis Cystolithiasis Cystic Calculi Cystic Calculus
Nephrolithiasis, Calcium Oxalate	Kidney Stones Calculus Of Kidney Kidney Calculi Nephrolithiasis Renal Calculi Calcium Oxalate Urolithiasis CAON Urolithiasis, Calcium Oxalate Calcium Oxalate Nephrolithiasis Kidney Stone Nephrolith Renal Calculus Urinary Stones Renal Stone Calculus, Kidney Calculus, Renal Renal Lithiasis Renal Stones Urolithiasis Renal Calculus Or Stone Stone In Kidney Nephritic Calculus Multiple Kidney Calculi Multiple Kidney Calculus Nephrolithiasis Nos Pelvic Nephrolithiasis Pelviolithiasis Pelvis Nephrolithiasis
Diastrophic Dysplasia	Diastrophic Dwarfism DTD Dd Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant Dysplasia, Diastrophic Diastrophic Dysplasia Variant
Hyperoxaluria, Primary, Type Iii	Primary Hyperoxaluria Type 3 HP3 Ph Iii Primary Hyperoxaluria Type Iii Hyperoxaluria Primary 3 Hyperoxaluria Non-Hp1/Non-Hp2 Hyperoxaluria Non-Ph I/Ph Ii Form Hyperoxaluria Primary Type Iii
Inflammatory Diarrhea
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159706	S9-A13	Inhibitor	/	Unkown
HY-154912	PAT1inh-B01	Inhibitor	98.04%	Unkown
HY-154912A	PAT1inh-B01 hydrochloride	Inhibitor	99.87%	Unkown
HY-162033	PAT1inh-A0030	Inhibitor	/	Unkown
HY-RS13140	SLC26A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22038	Slc26a6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28555	Slc26a6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC26A6	VGNC	VGNC:34781
Rattus norvegicus	SLC26A6	RGD	RGD:1310197
Mus musculus	SLC26A6	MGD	MGI:2159728
Macaca mulatta	SLC26A6	VGNC	VGNC:77483
Others	SLC26A6	NCBI