SLC20A2 - solute carrier family 20 member 2 Gene

Homo sapiens

Also known as PIT2; RAM1; GLVR2; IBGC1; IBGC2; IBGC3; MLVAR; PIT-2; Ram-1; GLVR-2

Gene ID: 6575 | Gene type: protein coding

About SLC20A2

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:42,416,475-42,541,954 (from NCBI)

This gene has 14 transcripts (splice variants), 220 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 23.3), heart (RPKM 12.0) and 24 other tissues.

Summary

This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral Infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

SLC20A2 Products(3)

mRNA	Protein	Name
NM_001257180.2	NP_001244109.1	sodium-dependent phosphate transporter 2
NM_001257181.2	NP_001244110.1	sodium-dependent phosphate transporter 2
NM_006749.5	NP_006740.1	sodium-dependent phosphate transporter 2

SLC20A2 Protein Structure

PHO4

0
100
200
300
400
500
600
652 a.a.

Protein Preferred Names

Protein Names

sodium-dependent phosphate transporter 2

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Basal Ganglia Calcification, Idiopathic, 1

Primary Familial Brain Calcification	Pfbc
Bspdc	Bilateral Striopallidodentate Calcinosis
Cerebrovascular Ferrocalcinosis	IBGC1
Familial Idiopathic Basal Ganglia Calcification	Idiopathic Basal Ganglia Calcification 1
Striopallidodentate Calcinosis, Bilateral	Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset
Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset	Ferrocalcinosis, Cerebrovascular
Fahr Disease, Familial, Formerly	Basal Ganglia Calcification, Idiopathic, 3, Formerly
Ibgc3, Formerly	Basal Ganglia Calcification, Idiopathic, 2, Formerly
Ibgc2, Formerly	Fibgc
Striopallidodentate Calcinosis	Idiopathic Basal Ganglia Calcification
Ferrocalcinosis Cerebro Vascular	Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis
Familial Fahr Disease	Ibgc2
Ibgc3	Idiopathic Basal Ganglia Calcification 2
Idiopathic Basal Ganglia Calcification 3	Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification
Basal Ganglia Calcification, Idiopathic	Calcification, Basal Ganglia, Idiopathic
Calcification, Basal Ganglia, Idiopathic, Type 1	Fahr'S Syndrome

Basal Ganglia Calcification

Fahr'S Syndrome	Fahr'S Disease
Fahr Disease

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Basal Ganglia Disease

Basal Ganglia Diseases	Basal Ganglia Disorders
Abnormality Of The Basal Ganglia

Kenny-Caffey Syndrome, Type 1

KCS1	Kenny-Caffey Syndrome Type 1
Autosomal Recessive Kenny-Caffey Syndrome	Kcs
Kenny-Caffey Syndrome, Autosomal Recessive	Kenny-Caffey Syndrome 1
Kenny-Caffey Syndrome Autosomal Recessive	Kenny-Caffey Syndrome-1

Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia	Oro-Facial Dyskinesia
Dyskinesias

Pulmonary Alveolar Microlithiasis

PULAM

Pam

Hypophosphatemic Rickets With Hypercalciuria, Hereditary

Hereditary Hypophosphatemic Rickets With Hypercalciuria	HHRH
Hypophosphatemic Rickets With Hypercalciuria	Hypercalciuric Rickets

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Aphasia

Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases

Phosphorus Metabolism Disease

Phosphorus Metabolism Disorders	Disorder Of Phosphorus Metabolism
Phosphorus Disorder	Phosphorus Metabolism Disorder

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Arterial Calcification Of Infancy

Idiopathic Infantile Arterial Calcification	Generalized Arterial Calcification Of Infancy
Iiac	Occlusive Infantile Arteriopathy
Infantile Arteriosclerosis	Gaci
Idiopathic Obliterative Arteriopathy	Generalized Arterial Calcification In Infancy
Arteriopathia Calcificans Infantum	Diffuse Arterial Calcifying Elastopathy Of Infancy
Infantile Calcifying Arteriopathy	Medial Coronary Sclerosis Of Infancy
Coronary Sclerosis, Medial, Of Infancy	Calcification, Arterial, Generalized, Infancy

Mineral Metabolism Disease

Mineral Metabolism Disorder

Disorder Of Mineral Metabolism

Hypophosphatemic Rickets, X-Linked Dominant

X-Linked Hypophosphatemia	Xlh
Vitamin D-Resistant Rickets, X-Linked	X-Linked Hypophosphatemic Rickets
XLHR	Hyp
Hypophosphatemic Vitamin D-Resistant Rickets	Hpdr
X-Linked Dominant Hypophosphatemic Rickets	Familial Hypophosphatemic Rickets
Hypophosphatemia, X-Linked	Hypophosphatemia, Vitamin D-Resistant Rickets
Hypophosphatemic Rickets X-Linked Dominant	X-Linked Vitamin D-Resistant Rickets
Hypophophatemia, X-Linked	Hypophophatemic Vitamin D-Resistant Rickets
Hypophosphatemia X-Linked	Vitamin D-Resistant Rickets X-Linked
Vitamin D-Resistant Rickets	Rickets, X-Linked Hypophosphatemic

Choreatic Disease

Chorea

Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13060	SLC20A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC20A2	RGD	RGD:3699
Mus musculus	SLC20A2	MGD	MGI:97851
Felis catus	SLC20A2	VGNC	VGNC:65237
Macaca mulatta	SLC20A2	VGNC	VGNC:77416
Canis familiaris	SLC20A2	VGNC	VGNC:46269
Bos taurus	SLC20A2	VGNC	VGNC:34718
Others	SLC20A2	NCBI

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