2. Gene
  3. Gemin2 - gem nuclear organelle associated protein 2 Gene

Gemin2 - gem nuclear organelle associated protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sip1; gemin-2

Gene ID: 66603 | Gene type: protein coding

About Gemin2

Summary

This gene encodes one of the proteins found in the survival of motor neuron (SMN) complex, which consists of the SMN protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal small nuclear ribonucleoproteins (snRNP) and for pre-mRNA splicing. This protein interacts directly with the SMN protein and it is required for formation of the SMN complex. Disruption of this gene in mouse resulted in impaired snRNP assembly, and motor neuron degeneration. [provided by RefSeq, Sep 2015]

Gemin2 Products(1)

mRNA Protein Name
NM_025656.5 NP_079932.2 gem-associated protein 2
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11181573 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11181573 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gem-associated protein 2

SMN-interacting protein 1

component of gems 2

survival of motor neuron protein-interacting protein 1

survivor of motor neuron protein interacting protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05367 GEMIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gemin2 NCBI NCBI:8487