Rnf220 - ring finger protein 220 Gene

Mus musculus

Also known as 4732477A13; 4931406I20Rik; 5730503K05Rik

Gene ID: 66743 | Gene type: protein coding

About Rnf220

Summary

Enables ubiquitin protein Ligase activity. Involved in protein autoubiquitination. Acts upstream of or within several processes, including nervous system development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Located in cytoplasm. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF220 (ring finger protein 220). [provided by Alliance of Genome Resources, Apr 2022]

Rnf220 Products(4)

mRNA	Protein	Name
NM_001310729.1	NP_001297658.1	E3 ubiquitin-protein ligase Rnf220 isoform 2
NM_001310730.1	NP_001297659.1	E3 ubiquitin-protein ligase Rnf220 isoform 3
NM_001310731.1	NP_001297660.1	E3 ubiquitin-protein ligase Rnf220 isoform 4
NM_025739.3	NP_080015.3	E3 ubiquitin-protein ligase Rnf220 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20170641	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	20170641	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20170641	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	30177510	MGI
acts upstream of or within noradrenergic neuron development	IMP IMP: Inferred from mutant phenotype	32094113	MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	32094113	MGI
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	20170641	MGI
acts upstream of or within protein monoubiquitination	IGI IGI: Inferred from genetic interaction	32094113	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	20170641	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	36179027	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: Inferred from expression pattern	36179027	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	36179027	MGI
acts upstream of or within regulation of transcription regulatory region DNA binding	IGI IGI: Inferred from genetic interaction	32094113	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20170641	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	36179027	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	36179027	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	36179027	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	36179027	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	36179027	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	36179027	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Rnf220

RING-type E3 ubiquitin transferase Rnf220

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12082	RNF220 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf220	NCBI	NCBI:55182

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