Tmem107 - transmembrane protein 107 Gene

Also Known as 1110004B13Rik; 2810049P21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 66910

Summary

Involved in several processes, including embryonic digit morphogenesis; non-motile cilium assembly; and protein localization to ciliary transition zone. Acts upstream of or within several processes, including craniofacial suture morphogenesis; detection of nodal flow; and roof of mouth development. Located in ciliary transition zone. Is expressed in brain ventricle and choroid plexus; nasal cavity epithelium; node; and pharynx. Human ortholog(s) of this gene implicated in Meckel syndrome 13 and orofaciodigital syndrome XVI. Orthologous to human TMEM107 (transmembrane protein 107). [provided by Alliance of Genome Resources, Apr 2022]

Tmem107 Products (4)

mRNA	Protein	Name
NM_025838.2	NP_080114.1	transmembrane protein 107 isoform 1
NM_028336.3	NP_082612.2	transmembrane protein 107 isoform 2
NM_025838.2	NP_080114.1	transmembrane protein 107 isoform 1
NM_028336.3	NP_082612.2	transmembrane protein 107 isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	31887266	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	22698544	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	28954202	MGI
acts upstream of or within craniofacial suture morphogenesis	IMP IMP: Inferred from mutant phenotype	28954202	MGI
acts upstream of or within detection of nodal flow	IMP IMP: Inferred from mutant phenotype	31887266	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	31887266	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	22698544	MGI
involved in neural tube patterning	IMP IMP: Inferred from mutant phenotype	22698544	MGI
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	26595381	MGI
involved in protein localization to ciliary transition zone	IMP IMP: Inferred from mutant phenotype	26595381	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28954202	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	28954202	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary transition zone	IDA IDA: Inferred from direct assay	26518474	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 107

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14648	TMEM107 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem107	NCBI	NCBI:84314