2. Gene
  3. Trim59 - tripartite motif-containing 59 Gene

Trim59 - tripartite motif-containing 59 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mrf1; TSBF1; 2310035M22Rik; 2700022F13Rik

Gene ID: 66949 | Gene type: protein coding

About Trim59

Summary

Enables ubiquitin protein Ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in endoplasmic reticulum. Is expressed in several structures, including Peyer's patch; genitourinary system; gut; nervous system; and skin. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Apr 2022]

Trim59 Products(1)

mRNA Protein Name
NM_025863.3 NP_080139.3 tripartite motif-containing protein 59
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22588174 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
22588174 MGI
Biological Process GO Annotation Evidence Reference Source
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
22588174 MGI
involved in negative regulation of viral entry into host cell IDA
IDA: Inferred from direct assay
18248090 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22588174 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tripartite motif-containing protein 59

RING finger 1

RING finger protein 1

tumor suppressor TSBF1 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15059 TRIM59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim59 NCBI NCBI:286827