SPRR1B - small proline rich protein 1B Gene

Homo sapiens

Also known as SPRR1; GADD33; SPR-IB; CORNIFIN

Gene ID: 6699 | Gene type: protein coding

About SPRR1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,031,203-153,032,900 (from NCBI)

This gene has 1 transcript (splice variant), 60 orthologues and 20 paralogues. Restricted expression toward esophagus (RPKM 644.6).

Summary

The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]

SPRR1B Products(1)

mRNA	Protein	Name
NM_003125.3	NP_003116.2	cornifin-B

SPRR1B Protein Structure

Cornifin

0
89 a.a.

Protein Preferred Names

Protein Names

cornifin-B

14.9 kDa pancornulin

Related Diseases

Diseases

Alias

Cervical Intraepithelial Neoplasia

CIN

Anus Benign Neoplasm

Anal Neoplasm	Anal Tumors
Neoplasm Of Anus	Anus Neoplasms

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13714	SPRR1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPRR1B	RGD	RGD:1587862
Mus musculus	SPRR1B	MGD	MGI:106659

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