Khdc3 - KH domain containing 3, subcortical maternal complex member Gene

Mus musculus

Also known as FILIA; OEEP48; 2410004A20Rik

Gene ID: 66991 | Gene type: protein coding

About Khdc3

Summary

Predicted to enable RNA binding activity. Involved in several processes, including positive regulation of dendrite development; positive regulation of double-strand break repair via homologous recombination; and positive regulation of embryonic development. Acts upstream of or within mitotic spindle assembly; mitotic spindle assembly checkpoint signaling; and protein phosphorylation. Located in several cellular components, including apical cortex; centrosome; and mitochondrion. Part of subcortical maternal complex. Is expressed in cranial ganglion; dorsal root ganglion; early conceptus; ovary; and vibrissa. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human KHDC3L (KH domain containing 3 like, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]

Khdc3 Products(2)

mRNA	Protein	Name
NM_001311106.1	NP_001298035.1	KH domain-containing protein 3 isoform 2
NM_025890.3	NP_080166.1	KH domain-containing protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18057100	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	31575650	MGI
involved in establishment of organelle localization	IMP IMP: Inferred from mutant phenotype	31575650	MGI
acts upstream of or within mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	19376971	MGI
acts upstream of or within mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	19376971	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25936915	MGI
involved in positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	33115731	MGI
involved in positive regulation of double-strand break repair	IMP IMP: Inferred from mutant phenotype	29125140	MGI
involved in positive regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	25936915	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	29125140	MGI
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	33115731	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19376971	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	25936915	MGI
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	29125140	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	18057100	MGI
located in centrosome	IDA IDA: Inferred from direct assay	25936915	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	25936915	MGI
located in nucleus	IDA IDA: Inferred from direct assay	25936915	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	18057100	MGI
part of subcortical maternal complex	IDA IDA: Inferred from direct assay	18057100	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

KH domain-containing protein 3

protein Filia

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07235	KHDC3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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