Khdc3 - KH domain containing 3, subcortical maternal complex member Gene

Also Known as FILIA; OEEP48; 2410004A20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66991

Summary

Predicted to enable RNA binding activity. Involved in several processes, including positive regulation of dendrite development; positive regulation of double-strand break repair via homologous recombination; and positive regulation of embryonic development. Acts upstream of or within mitotic spindle assembly; mitotic spindle assembly checkpoint signaling; and protein phosphorylation. Located in several cellular components, including apical cortex; centrosome; and mitochondrion. Part of subcortical maternal complex. Is expressed in cranial ganglion; dorsal root ganglion; early conceptus; ovary; and vibrissa. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human KHDC3L (KH domain containing 3 like, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]

Khdc3 Products (2)

mRNA Protein Name
NM_001311106.1 NP_001298035.1 KH domain-containing protein 3 isoform 2
NM_025890.3 NP_080166.1 KH domain-containing protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18057100 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
31575650 MGI
involved in establishment of organelle localization IMP
IMP: Inferred from mutant phenotype
31575650 MGI
acts upstream of or within mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
19376971 MGI
acts upstream of or within mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
19376971 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25936915 MGI
involved in positive regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
33115731 MGI
involved in positive regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
29125140 MGI
involved in positive regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
25936915 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
29125140 MGI
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
33115731 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19376971 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
25936915 MGI
involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
29125140 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
18057100 MGI
located in centrosome IDA
IDA: Inferred from direct assay
25936915 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
25936915 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25936915 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
18057100 MGI
part of subcortical maternal complex IDA
IDA: Inferred from direct assay
18057100 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

KH domain-containing protein 3

  • protein Filia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07235 KHDC3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown