SRI - sorcin Gene

Also Known as SCN; V19; CP22; CP-22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6717

About SRI

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:88,205,115-88,226,976 (from NCBI)

This gene has 10 transcripts (splice variants), 173 orthologues and 20 paralogues. Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues.

Summary

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

SRI Products (4)

mRNA	Protein	Name
NM_001256891.2	NP_001243820.1	sorcin isoform C
NM_001256892.2	NP_001243821.1	sorcin isoform D
NM_003130.4	NP_003121.1	sorcin isoform A
NM_198901.2	NP_944490.1	sorcin isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	17215369	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17699613	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	10748169	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9268363	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	12804766	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of heart rate	IMP IMP: Inferred from mutant phenotype	12754254	GOA
involved in negative regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	17699613	GOA
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	12754254	GOA
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	12754254	GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	17130302	GOA
involved in regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	12754254	GOA
involved in regulation of relaxation of muscle	IMP IMP: Inferred from mutant phenotype	12754254	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	12754254	GOA
colocalizes with chromaffin granule membrane	IDA IDA: Inferred from direct assay	9268363	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10748169	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10672515	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in membrane	IDA IDA: Inferred from direct assay	10748169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRI Protein Structure

EF-hand_8

EF-hand_7

0
100
198 a.a.

Protein Preferred Names	Protein Names
sorcin	22 kDa protein

SRI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SRI	P30626	PDE4C	Homo sapiens	Q08493-3	Y2H Prey Pooling	25416956
Intra	SRI	P30626	PDE4C	Homo sapiens	Q08493-2	Validated Y2H	32296183
Intra	SRI	P30626	STAT3	Homo sapiens	P40763	Y2H	18330356
Intra	SRI	P30626	STAT3	Homo sapiens	P40763	Pull Down	21988832
Intra	SRI	P30626	STAT3	Homo sapiens	P40763	Y2H	21988832
Intra	SRI	P30626	TCF12	Homo sapiens	Q99081	Y2H Array	25416956
Intra	SRI	P30626	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	SRI	P30626	CALCOCO2	Homo sapiens	Q13137	Y2H Pooling	16189514
Intra	SRI	P30626	CALCOCO2	Homo sapiens	Q13137	Y2H	18330356
Intra	SRI	P30626	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	SRI	P30626	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	25416956
Intra	SRI	P30626	PRR13	Homo sapiens	Q9NZ81	Y2H Array	25416956
Intra	SRI	P30626	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SRI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77210	Sorcin/SRI Protein, Human (sf9)	P30626 (M1-V198)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77211	Sorcin/SRI Protein, Human (sf9, His-GST)	P30626 (M1-V198)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700311	Sorcin/SRI Protein, Human (E.coli, GST)	P30626 (M1-V198)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Overhydrated Hereditary Stomatocytosis	Ohs Potassium Sodium Disorder Of Erythrocyte OHST Stomatocytosis I Potassium-Sodium Disorder Of Erythrocyte Stomatocytosisiohst Hereditary, Overhydrated, Cation-Leak Stomatocytosis Overhydrated Cation Leak Stomatocytosis Stomatocytosis, Overhydrated Hereditary
Apical Myocardial Infarction
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100347	SRI-011381	Agonist	99.58%	Unkown
HY-19956	GI254023X	Inhibitor	99.67%	Unkown
HY-100347A	SRI-011381 hydrochloride	Agonist	99.94%	Unkown
HY-150090	SRI-41315	Activator	99.68%	Unkown
HY-141623	SRI-37330 hydrochloride	Inhibitor	99.72%	Unkown
HY-142114	SRI-37330	Inhibitor	99.16%	Unkown
HY-148853	SRI-42127	Inhibitor	99.80%	Unkown
HY-114363A	SRI 31215 TFA	Inhibitor	98.35%	Unkown
HY-123600	SRI-29329	Inhibitor	99.14%	Unkown
HY-150089	SRI-37240	Modulator	98.29%	Unkown
HY-117002	SRI 37892	Inhibitor	99.28%	Unkown
HY-147251	SRI 6409-94		99.25%	Unkown
HY-160783	SRI-43265	Inhibitor	98.70%	Unkown
HY-178061	APS03118	Inhibitor	/	Unkown
HY-117902	SRI-31142		99.89%	Unkown
HY-75368	SRI-31255	Inhibitor	99.88%	Unkown
HY-112580	SRI-31040		/	Unkown
HY-114363	SRI 31215	Inhibitor	/	Unkown
HY-126158	SRI-29574		/	Unkown
HY-165543	SRI-29132	Inhibitor	/	Unkown
HY-175661	SRI-22136		/	Unkown
HY-182446	SRI-22818	Activator	/	Unkown
HY-182611	SRI-31277		/	Unkown
HY-182612	SRI-35241	Antagonist	/	Unkown
HY-RS13767	SRI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100347S	SRI-011381-d5	Agonist	/	Unkown
HY-175534	SRI-45949	Modulator	/	Unkown
HY-175535	SRI-32743		/	Unkown
HY-N9533	16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid		/	Unkown
HY-RS17159	Sri Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23609	Sri Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRI	RGD	RGD:1584485
Canis familiaris	SRI	VGNC	VGNC:46804
Macaca mulatta	SRI	VGNC	VGNC:81763
Mus musculus	SRI	MGD	MGI:98419
Felis catus	SRI	VGNC	VGNC:65681
Bos taurus	SRI	VGNC	VGNC:35281
Macaca fascicularis	SRI	NCBI	NCBI:102138728
Others	SRI	NCBI