SRI - sorcin Gene

Homo sapiens

Also known as SCN; V19; CP22; CP-22

Gene ID: 6717 | Gene type: protein coding

About SRI

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:88,205,115-88,226,976 (from NCBI)

This gene has 10 transcripts (splice variants), 173 orthologues and 20 paralogues. Broad expression in colon (RPKM 86.4), brain (RPKM 64.5) and 24 other tissues.

Summary

This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012]

SRI Products(4)

mRNA	Protein	Name
NM_001256891.2	NP_001243820.1	sorcin isoform C
NM_001256892.2	NP_001243821.1	sorcin isoform D
NM_003130.4	NP_003121.1	sorcin isoform A
NM_198901.2	NP_944490.1	sorcin isoform B

SRI Protein Structure

EF-hand_8

EF-hand_7

0
100
198 a.a.

Protein Preferred Names

Protein Names

sorcin

22 kDa protein

Recombinant SRI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77210	Sorcin/SRI Protein, Human (sf9)	P30626 (M1-V198)	≥95%
HY-P77211	Sorcin/SRI Protein, Human (sf9, His-GST)	P30626 (M1-V198)	≥95%
HY-P700311	Sorcin/SRI Protein, Human (E.coli, GST)	P30626 (M1-V198)	≥95%

Related Diseases

Diseases

Alias

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Apical Myocardial Infarction

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100347A	SRI-011381 hydrochloride	Agonist	99.55%	Unkown
HY-19956	GI254023X	Inhibitor	99.67%	Unkown
HY-100347	SRI-011381		99.58%	Unkown
HY-142114	SRI-37330	Inhibitor	98.76%	Unkown
HY-141623	SRI-37330 hydrochloride	Inhibitor	99.05%	Unkown
HY-114363A	SRI 31215 TFA	Inhibitor	98.81%	Unkown
HY-150090	SRI-41315	Activator	99.94%	Unkown
HY-150089	SRI-37240	Modulator	99.21%	Unkown
HY-148853	SRI-42127	Inhibitor	99.64%	Unkown
HY-123600	SRI-29329	Inhibitor	99.73%	Unkown
HY-117002	SRI 37892	Inhibitor	98.92%	Unkown
HY-147251	SRI 6409-94		98.60%	Unkown
HY-160783	SRI-43265	Inhibitor	99.08%	Unkown
HY-RS13767	SRI Human Pre-designed siRNA Set A		/	Unkown
HY-N9533	16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SRI	RGD	RGD:1584485
Canis familiaris	SRI	VGNC	VGNC:46804
Macaca mulatta	SRI	VGNC	VGNC:81763
Mus musculus	SRI	MGD	MGI:98419
Felis catus	SRI	VGNC	VGNC:65681
Bos taurus	SRI	VGNC	VGNC:35281
Macaca fascicularis	SRI	NCBI
Others	SRI	NCBI

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