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  4. Sorcin/SRI Protein, Human (E.coli, GST)

Sorcin/SRI Protein, Human (E.coli, GST)

Cat. No.: HY-P700311
Handling Instructions

The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (E.coli, GST) is the recombinant human-derived Sorcin/SRI protein, expressed by E. coli , with N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (E.coli, GST) is 198 a.a., with molecular weight of ~48 kDa.

For research use only. We do not sell to patients.

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Description

The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (E.coli, GST) is the recombinant human-derived Sorcin/SRI protein, expressed by E. coli , with N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (E.coli, GST) is 198 a.a., with molecular weight of ~48 kDa.
Background

Sorcin (SRI) is a calcium-binding protein crucial for regulating excitation-contraction coupling in the heart, playing a significant role in maintaining calcium homeostasis within the sarcoplasmic reticulum. SRI has been identified as a modulator of RYR2 calcium channels, suggesting its involvement in finely tuning intracellular calcium dynamics. Existing as a homodimer, SRI also engages in protein-protein interactions, forming complexes with GCA, RYR2, and ANXA7.
Species

Human
Source

E. coli
Tag

N-GST
Accession

P30626 (M1-V198)
Gene ID
Molecular Construction
N-term
GST
SRI (M1-V198)
Accession # P30626
C-term
Synonyms
22 kDa protein; CP22; V19
Molecular Weight

Approximately 48 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/ug, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Sorcin/SRI Protein, Human (E.coli, GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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