1. Cell Cycle/DNA Damage
  2. CDK
  3. SRI-29329

SRI-29329 

Cat. No.: HY-123600
Handling Instructions

SRI-29329 is a specific CLK inhibitor, with IC50 values of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively.

For research use only. We do not sell to patients.

SRI-29329 Chemical Structure

SRI-29329 Chemical Structure

CAS No. : 2086809-58-5

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10 mg USD 400 Ask For Quote & Lead Time
25 mg USD 750 Ask For Quote & Lead Time
50 mg USD 1150 Ask For Quote & Lead Time

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Description

SRI-29329 is a specific CLK inhibitor, with IC50 values of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively[1].

In Vitro

SRI-29329 (compound 8) shows some modest (~5 fold) selectivity for CLK2 over CLK1 and CLK4 without significant CDK1,4,6 activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.92

Formula

C₂₀H₂₆ClN₇

CAS No.

2086809-58-5

SMILES

CC(N1C=NC2=C(NC3=CC=CC(Cl)=C3)N=C(N[[email protected]]4CCCC[[email protected]@H]4N)N=C12)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (125.03 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5005 mL 12.5025 mL 25.0050 mL
5 mM 0.5001 mL 2.5005 mL 5.0010 mL
10 mM 0.2501 mL 1.2502 mL 2.5005 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (6.25 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

SRI-29329SRI29329SRI 29329CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product Name:
SRI-29329
Cat. No.:
HY-123600
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