Ift172 - intraflagellar transport 172 Gene

Mus musculus

Also known as Slb; wim; avc1; 4930553F24Rik

Gene ID: 67661 | Gene type: protein coding

About Ift172

Summary

Involved in smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of smoothened signaling pathway. Located in sperm cytoplasmic droplet; sperm midpiece; and sperm principal piece. Part of intraciliary transport particle B. Is expressed in several structures, including brain; endocrine gland; genitourinary system; olfactory epithelium; and trachea. Used to study VACTERL association; atrioventricular septal defect; and retinal degeneration. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172). [provided by Alliance of Genome Resources, Apr 2022]

Ift172 Products(1)

mRNA	Protein	Name
NM_026298.5	NP_080574.5	intraflagellar transport protein 172 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11062270	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	21653639	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	18488998	MGI
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	14603322	MGI
acts upstream of or within cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	15755804	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	16061793	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	14603322	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	28778798	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	21653639	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within hindgut development	IMP IMP: Inferred from mutant phenotype	21653639	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within left/right axis specification	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	28778798	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	19521792	MGI
acts upstream of or within neural tube formation	IMP IMP: Inferred from mutant phenotype	14603322	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	18930042	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18488998	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	16061793	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21653639	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	21653639	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11062270	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21552265	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	14603322	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	23055941	MGI
located in sperm cytoplasmic droplet	IDA IDA: Inferred from direct assay	24339785	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	23055941	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	23055941	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 172 homolog

intraflagellar transport 172 homolog	intraflagellar transport 172 protein
protein wimple	selective LIM-binding factor Wimple

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06600	IFT172 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ift172	NCBI	NCBI:26160

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