Ift172 - intraflagellar transport 172 Gene

Also Known as Slb; wim; avc1; 4930553F24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67661

Summary

Involved in smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of smoothened signaling pathway. Located in sperm cytoplasmic droplet; sperm midpiece; and sperm principal piece. Part of intraciliary transport particle B. Is expressed in several structures, including brain; endocrine gland; genitourinary system; olfactory epithelium; and trachea. Used to study VACTERL association; atrioventricular septal defect; and retinal degeneration. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 20; retinitis pigmentosa 71; and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172). [provided by Alliance of Genome Resources, Apr 2022]

Ift172 Products (1)

mRNA Protein Name
NM_026298.5 NP_080574.5 intraflagellar transport protein 172 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11062270 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
21653639 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
18488998 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
14603322 MGI
acts upstream of or within cytoplasmic microtubule organization IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
15755804 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
16061793 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
14603322 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
28778798 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
21653639 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within hindgut development IMP
IMP: Inferred from mutant phenotype
21653639 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within left/right axis specification IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
28778798 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
19521792 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
14603322 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
18930042 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
18488998 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
16061793 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21653639 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
21653639 MGI
involved in smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
11062270 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
21552265 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
14603322 MGI
part of intraciliary transport particle B IDA
IDA: Inferred from direct assay
23055941 MGI
located in sperm cytoplasmic droplet IDA
IDA: Inferred from direct assay
24339785 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
23055941 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
23055941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 172 homolog

  • intraflagellar transport 172 homolog

  • intraflagellar transport 172 protein

  • protein wimple

  • selective LIM-binding factor Wimple

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06600 IFT172 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift172 NCBI NCBI:26160