Cgnl1 - cingulin-like 1 Gene

Also Known as Jacop; 4933421H10Rik; 9930020M10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68178

Summary

This gene encodes a protein localized to the tight junctions and adherens junctions in vertebrate epithelial cells. The encoded protein regulates the activity of Rho family GTPases during junction assembly and at confluence. At the adherens junctions, the encoded protein is part of a protein complex that links E-cadherin to the microtubule Cytoskeleton. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Cgnl1 Products (3)

mRNA Protein Name
NM_001304362.2 NP_001291291.1 cingulin-like protein 1
NM_001407857.1 NP_001394786.1 cingulin-like protein 1
NM_026599.6 NP_080875.3 cingulin-like protein 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
15292197 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
15292197 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
22946046 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cingulin-like protein 1

  • junction-associated coiled-coil protein

  • paracingulin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02586 CGNL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cgnl1 NCBI NCBI:84952