Ift80 - intraflagellar transport 80 Gene

Mus musculus

Also known as Wdr56; mKIAA1374; 4921524P20Rik

Gene ID: 68259 | Gene type: protein coding

About Ift80

Summary

Involved in non-motile cilium assembly. Acts upstream of or within several processes, including osteoblast proliferation; receptor localization to non-motile cilium; and skeletal system development. Located in 9+0 non-motile cilium; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in diencephalon lateral wall ventricular layer; hypothalamus ventricular layer; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Used to study asphyxiating thoracic dystrophy 2 and asphyxiating thoracic dystrophy 3. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80). [provided by Alliance of Genome Resources, Apr 2022]

Ift80 Products(1)

mRNA	Protein	Name
NM_026641.2	NP_080917.1	intraflagellar transport protein 80 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35733270	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within articular cartilage development	IMP IMP: Inferred from mutant phenotype	26098911	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within bone mineralization involved in bone maturation	IMP IMP: Inferred from mutant phenotype	26996322	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	21227999	MGI
acts upstream of or within canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within cartilage homeostasis	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	23333501	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23333501	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	23333501	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	26098911	MGI
acts upstream of or within establishment or maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within growth plate cartilage chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	26098911	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	26098911	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	26098911	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	26053317	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	21703454	MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23333501	MGI
acts upstream of non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23333501	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21703454	MGI
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	26996322	MGI
acts upstream of or within odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within odontogenesis	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	22771375	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	22771375	MGI
acts upstream of or within osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	26996322	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within protein ubiquitination	IMP IMP: Inferred from mutant phenotype	35733270	MGI
acts upstream of or within receptor localization to non-motile cilium	IMP IMP: Inferred from mutant phenotype	26996322	MGI
acts upstream of or within response to inositol	IDA IDA: Inferred from direct assay	34093381	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	26996322	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21227999	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	30683845	MGI
acts upstream of or within tissue development	IMP IMP: Inferred from mutant phenotype	32227389	MGI
acts upstream of or within tooth eruption	IMP IMP: Inferred from mutant phenotype	30683845	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in 9+0 non-motile cilium	IDA IDA: Inferred from direct assay	26996322	MGI
located in centrosome	IDA IDA: Inferred from direct assay	19253336	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	26996322	MGI
located in cilium	IDA IDA: Inferred from direct assay	19253336	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	19253336	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intraflagellar transport protein 80 homolog

WD repeat domain 56	WD repeat-containing protein 56
intraflagellar transport 80 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06608	IFT80 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ift80	NCBI	NCBI:57560

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