Ift80 - intraflagellar transport 80 Gene

Also Known as Wdr56; mKIAA1374; 4921524P20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68259

Summary

Involved in non-motile cilium assembly. Acts upstream of or within several processes, including osteoblast proliferation; receptor localization to non-motile cilium; and skeletal system development. Located in 9+0 non-motile cilium; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in diencephalon lateral wall ventricular layer; hypothalamus ventricular layer; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Used to study asphyxiating thoracic dystrophy 2 and asphyxiating thoracic dystrophy 3. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 2. Orthologous to human IFT80 (intraflagellar transport 80). [provided by Alliance of Genome Resources, Apr 2022]

Ift80 Products (1)

mRNA Protein Name
NM_026641.2 NP_080917.1 intraflagellar transport protein 80 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35733270 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within articular cartilage development IMP
IMP: Inferred from mutant phenotype
26098911 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within bone mineralization involved in bone maturation IMP
IMP: Inferred from mutant phenotype
26996322 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
21227999 MGI
acts upstream of or within canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within cartilage homeostasis IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
23333501 MGI
acts upstream of or within chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
23333501 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
23333501 MGI
acts upstream of or within cilium organization IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
26098911 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within growth plate cartilage chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
26098911 MGI
acts upstream of or within growth plate cartilage development IMP
IMP: Inferred from mutant phenotype
26098911 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
26098911 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
26053317 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within negative regulation of non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
23333501 MGI
acts upstream of non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
23333501 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21703454 MGI
involved in non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
26996322 MGI
acts upstream of or within odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within odontogenesis IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
22771375 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
22771375 MGI
acts upstream of or within osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
26996322 MGI
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within protein stabilization IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within protein ubiquitination IMP
IMP: Inferred from mutant phenotype
35733270 MGI
acts upstream of or within receptor localization to non-motile cilium IMP
IMP: Inferred from mutant phenotype
26996322 MGI
acts upstream of or within response to inositol IDA
IDA: Inferred from direct assay
34093381 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
26996322 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21227999 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
30683845 MGI
acts upstream of or within tissue development IMP
IMP: Inferred from mutant phenotype
32227389 MGI
acts upstream of or within tooth eruption IMP
IMP: Inferred from mutant phenotype
30683845 MGI
Cellular Component GO Annotation Evidence References Source
is active in 9+0 non-motile cilium IDA
IDA: Inferred from direct assay
26996322 MGI
located in centrosome IDA
IDA: Inferred from direct assay
19253336 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
26996322 MGI
located in cilium IDA
IDA: Inferred from direct assay
19253336 MGI
part of intraciliary transport particle B IDA
IDA: Inferred from direct assay
19253336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 80 homolog

  • WD repeat domain 56

  • WD repeat-containing protein 56

  • intraflagellar transport 80 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06608 IFT80 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift80 NCBI NCBI:57560