SYT5 - synaptotagmin 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6861

About SYT5

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,171,196-55,180,289 (from NCBI)

This gene has 11 transcripts (splice variants), 102 orthologues and 31 paralogues. Biased expression in brain (RPKM 20.3) and adrenal (RPKM 2.1).

Summary

Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

SYT5 Products (2)

mRNA Protein Name
NM_001297774.2 NP_001284703.1 synaptotagmin-5 isoform 2
NM_003180.3 NP_003171.2 synaptotagmin-5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
27793683 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT5 Protein Structure

C2

C2: C2 domain (125 - 211)

C2

C2: C2 domain (256 - 343)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

synaptotagmin-5

  • synaptotagmin V

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14117 SYT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SYT5 VGNC VGNC:35544
Mus musculus SYT5 MGD MGI:1926368
Macaca mulatta SYT5 VGNC VGNC:78077
Rattus norvegicus SYT5 RGD RGD:3806
Felis catus SYT5 VGNC VGNC:65900
Canis familiaris SYT5 VGNC VGNC:47048
Others SYT5 NCBI