Prrt2 - proline-rich transmembrane protein 2 Gene

Also Known as DSPB3; 1500031I19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 69017

Summary

Enables syntaxin-1 binding activity. Involved in negative regulation of SNARE complex assembly; negative regulation of short-term synaptic potentiation; and synaptic vesicle exocytosis. Located in axon terminus; presynaptic membrane; and synaptic vesicle. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in brain. Used to study episodic kinesigenic dyskinesia 1. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Prrt2 Products (1)

mRNA	Protein	Name
NM_001102563.1	NP_001096033.1	proline-rich transmembrane protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27052163	MGI
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	29056747	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of SNARE complex assembly	IMP IMP: Inferred from mutant phenotype	29056747	MGI
involved in negative regulation of short-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	29056747	MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	27052163	MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	27052163	MGI
involved in synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	27052163	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon terminus	IDA IDA: Inferred from direct assay	29056747	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27052163	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27052163	MGI
located in membrane	IDA IDA: Inferred from direct assay	22101681	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	26797119	MGI
located in presynapse	IDA IDA: Inferred from direct assay	27052163	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	27052163	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	27052163	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	27052163	MGI
is active in presynaptic membrane	IMP IMP: Inferred from mutant phenotype	27052163	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	27052163	MGI
located in vesicle	IDA IDA: Inferred from direct assay	29056747	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
proline-rich transmembrane protein 2	dispanin subfamily B member 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11242	PRRT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prrt2	NCBI	NCBI:112476