2. Gene
  3. Selenot - selenoprotein T Gene

Selenot - selenoprotein T Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Selt; 2810407C02Rik; 5730408P04Rik

Gene ID: 69227 | Gene type: protein coding

About Selenot

Summary

This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017]

Selenot Products(1)

mRNA Protein Name
NM_001040396.3 NP_001035486.2 thioredoxin reductase-like selenoprotein T precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
26866473 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23913443 MGI
acts upstream of or within insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
23913443 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
23913443 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
23913443 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23913443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin reductase-like selenoprotein T

thioredoxin reductase-like enzyme

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12643 SELENOT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selenot NCBI NCBI:51714