Lypd8 - LY6/PLAUR domain containing 8 Gene

Also Known as 2210415F13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70163

Summary

This gene encodes a member of the Ly6/PLAUR family of cysteine-rich proteins that plays an important role in the protection of colonic epithelium from flagellated microbiota. The encoded protein undergoes proteolytic processing to generate a mature, glycosylphosphatidylinositol-anchored protein that is localized to the apical surface of the colonic epithelial cells. Mice lacking the encoded protein are sensitive to chemically induced intestinal inflammation. [provided by RefSeq, Aug 2016]

Lypd8 Products (3)

mRNA Protein Name
NM_001083884.1 NP_001077353.1 ly6/PLAUR domain-containing protein 8 preproprotein
NM_001330197.1 NP_001317126.1 ly6/PLAUR domain-containing protein 8 preproprotein
NM_027339.2 NP_081615.2 ly6/PLAUR domain-containing protein 8 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
27027293 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
27027293 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ly6/PLAUR domain-containing protein 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07920 LYPD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lypd8 NCBI NCBI:646627