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TGM4 - transglutaminase 4 Gene

Also Known as TGP; hTGP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7047

About TGM4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,874,608-44,914,990 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 72 orthologues and 8 paralogues. Restricted expression toward prostate (RPKM 891.0).

Summary

Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Located in Golgi apparatus and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

TGM4 Products (1)

mRNA	Protein	Name
NM_003241.4	NP_003232.2	protein-glutamine gamma-glutamyltransferase 4

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20569004	GOA
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	20596668	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20596668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TGM4 Protein Structure

Transglut_N

Transglut_core

Transglut_C

0
200
400
600
684 a.a.

Protein Preferred Names	Protein Names
protein-glutamine gamma-glutamyltransferase 4	TG(P)

TGM4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89639	TGase4 Antibody (YA8983)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Essential Tremor	Benign Essential Tremor Familial Tremor Hereditary Essential Tremor Essential Hereditary Tremor Shaky Hand Syndrome Benign Essential Tremor Syndrome Tremor Hereditary Essential Essential Tremor, Susceptibility To Tremor, Hereditary Essential
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pelvic Varices	Varix Of Pelvis Pelvic Varicose Vein

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14461	TGM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TGM4	RGD	RGD:620785
Mus musculus	TGM4	MGD	MGI:3027002
Macaca mulatta	TGM4	VGNC	VGNC:110335
Others	TGM4	NCBI