Dlg5 - discs large MAGUK scaffold protein 5 Gene

Mus musculus

Also known as mKIAA0583; 4933429D20Rik

Gene ID: 71228 | Gene type: protein coding

About Dlg5

Summary

Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Involved in positive regulation of dendritic spine development; positive regulation of synapse assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; apical protein localization; and protein localization to adherens junction. Located in adherens junction; ciliary basal body; and postsynaptic density. Is expressed in several structures, including alimentary system; hemolymphoid system gland; lung; nervous system; and reproductive system. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Dlg5 Products(2)

mRNA	Protein	Name
NM_001163513.1	NP_001156985.1	disks large homolog 5 isoform 1
NM_027726.1	NP_082002.1	disks large homolog 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17765678	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	23466739	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	23466739	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	23466739	MGI
acts upstream of or within metanephric collecting duct development	IMP IMP: Inferred from mutant phenotype	17765678	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	17765678	MGI
involved in negative regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	28087714	MGI
acts upstream of or within neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17765678	MGI
acts upstream of or within polarized epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17765678	MGI
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	25232112	MGI
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	25644602	MGI
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	25232112	MGI
involved in postsynapse organization	IDA IDA: Inferred from direct assay	25232112	MGI
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	25232112	MGI
acts upstream of or within protein localization to adherens junction	IMP IMP: Inferred from mutant phenotype	17765678	MGI
acts upstream of or within protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	17765678	MGI
acts upstream of or within zonula adherens assembly	IMP IMP: Inferred from mutant phenotype	17765678	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	12657639	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	25644602	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25232112	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	25232112	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25232112	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	25232112	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	25232112	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	25232112	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disks large homolog 5

discs, large homolog 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03800	DLG5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg5	NCBI	NCBI:9231

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