Myo1e - myosin IE Gene

Also Known as myr 3; myosin-1e; 2310020N23Rik; 9130023P14Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 71602

Summary

Predicted to enable several functions, including actin filament binding activity; Calmodulin binding activity; and microfilament motor activity. Involved in glomerular basement membrane development; glomerular filtration; and glomerular visceral epithelial cell development. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; post-embryonic hemopoiesis; and vasculogenesis. Located in adherens junction; brush border; and cytoplasm. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (Myosin IE). [provided by Alliance of Genome Resources, Apr 2022]

Myo1e Products (1)

mRNA	Protein	Name
NM_181072.3	NP_851417.2	unconventional myosin-Ie

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within excretion	IMP IMP: Inferred from mutant phenotype	17143286	MGI
involved in glomerular basement membrane development	IMP IMP: Inferred from mutant phenotype	19005011	MGI
involved in glomerular filtration	IMP IMP: Inferred from mutant phenotype	19005011	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17143286	MGI
involved in podocyte development	IMP IMP: Inferred from mutant phenotype	19005011	MGI
acts upstream of or within post-embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	17143286	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	19005011	MGI
located in brush border	IDA IDA: Inferred from direct assay	20089841	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19005011	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
unconventional myosin-Ie	molecular motor unconventional myosin 1E

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08941	MYO1E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21659	Myo1c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myo1e	NCBI	NCBI:4643