Ap2b1 - adaptor-related protein complex 2, beta 1 subunit Gene

Also Known as AP105B; 1300012O03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 71770

Summary

Predicted to enable clathrin binding activity. Involved in clathrin-dependent endocytosis and postsynaptic neurotransmitter receptor internalization. Acts upstream of or within circulatory system development and kidney development. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AP2B1 (adaptor related protein complex 2 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap2b1 Products (2)

mRNA	Protein	Name
NM_001035854.2	NP_001030931.1	AP-2 complex subunit beta isoform a
NM_027915.3	NP_082191.1	AP-2 complex subunit beta isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17290217	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	23676497	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
involved in postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	24217640	MGI
involved in postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	24217640	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	23676497	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24217640	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24217640	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
AP-2 complex subunit beta	adapter-related protein complex 2 beta subunit adapter-related protein complex 2 subunit beta adaptor protein complex AP-2 subunit beta adaptor-related protein complex 2 subunit beta beta-2-adaptin beta-adaptin beta2-adaptin clathrin assembly prote

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00786	AP2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ap2b1	NCBI	NCBI:163