TPTE - transmembrane phosphatase with tensin homology Gene

Also Known as CT44; PTEN2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7179

About TPTE

Cytogenetic location: 21p11.2 Genomic coordinates (GRCh38): 21:10,521,583-10,605,716 (from NCBI)

This gene has 5 transcripts (splice variants), 182 orthologues and 6 paralogues. Restricted expression toward testis (RPKM 57.8).

Summary

This gene encodes a PTEN-related tyrosine Phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

TPTE Products (4)

mRNA Protein Name
NM_001290224.2 NP_001277153.2 putative tyrosine-protein phosphatase TPTE isoform delta
NM_199259.4 NP_954868.2 putative tyrosine-protein phosphatase TPTE isoform beta
NM_199260.4 NP_954869.2 putative tyrosine-protein phosphatase TPTE isoform gamma
NM_199261.4 NP_954870.3 putative tyrosine-protein phosphatase TPTE isoform alpha

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPTE Protein Structure

Ion_trans

Ion_trans: Ion transport protein (131 - 220)

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (285 - 383)

PTEN_C2

PTEN_C2: C2 domain of PTEN tumour-suppressor protein (409 - 538)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 551 a.a.
Protein Preferred Names Protein Names

putative tyrosine-protein phosphatase TPTE

  • PTEN-related tyrosine phosphatase

Related Diseases

Diseases Alias
Brain Glioblastoma Multiforme

  • Brain Glioblastoma

  • Glioblastoma Multiforme Of Brain

  • Glioblastoma Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14957 TPTE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14958 TPTE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TPTE MGD MGI:2446460