Nkiras2 - NFKB inhibitor interacting Ras-like protein 2 Gene

Mus musculus

Also known as KBRAS2; 2410003M04Rik; 4930527H08Rik; D630018G21Rik

Gene ID: 71966 | Gene type: protein coding

About Nkiras2

Summary

Enables GTPase activating protein binding activity. Acts upstream of or within several processes, including Ral protein signal transduction; regulation of signal transduction; and surfactant homeostasis. Predicted to be located in cytoplasm. Is expressed in cerebral cortex; dorsal root ganglion; and nose. Orthologous to human NKIRAS2 (NFKB inhibitor interacting Ras like 2). [provided by Alliance of Genome Resources, Apr 2022]

Nkiras2 Products(1)

mRNA	Protein	Name
NM_028024.2	NP_082300.1	NF-kappa-B inhibitor-interacting Ras-like protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	25220458	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Ral protein signal transduction	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of or within inflammatory response	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	25220458	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of or within regulation of canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of or within regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25220458	MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	25220458	MGI
acts upstream of or within surfactant homeostasis	IGI IGI: Inferred from genetic interaction	25220458	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor-interacting Ras-like protein 2

I-kappa-B-interacting Ras-like protein 2	kappa B-Ras protein 2
kappaB-Ras2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09321	NKIRAS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkiras2	NCBI	NCBI:28511

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