Zbtb46 - zinc finger and BTB domain containing 46 Gene

Also Known as BZEL; Btbd4; 2610019F01Rik; 4933406L05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 72147

Summary

Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of leukocyte differentiation. Predicted to be active in nucleus. Is expressed in several structures, including brown fat; central nervous system; gonad; renal vasculature; and spleen. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb46 Products (2)

mRNA	Protein	Name
NM_027656.2	NP_081932.1	zinc finger and BTB domain-containing protein 46 isoform 1
NM_028125.3	NP_082401.1	zinc finger and BTB domain-containing protein 46 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22851594	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22370726	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	22851594	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within negative regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within negative regulation of granulocyte differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within negative regulation of leukocyte activation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within negative regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within negative regulation of monocyte differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22851594	MGI
acts upstream of plasmacytoid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI
acts upstream of or within positive regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	22615127	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	22851594	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger and BTB domain-containing protein 46	BTB (POZ) domain containing 4 BTB-ZF protein expressed in effector lymphocytes BTB/POZ domain-containing protein 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15977	ZBTB46 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zbtb46	NCBI	NCBI:140685