2. Gene
  3. Mir221 - microRNA 221 Gene

Mir221 - microRNA 221 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mirn221; mir-221; mmu-mir-221

Gene ID: 723827 | Gene type: ncRNA

About Mir221

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
16682203 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cellular response to decreased oxygen levels IEP
IEP: Inferred from expression pattern
19147652 MGI
acts upstream of or within cellular response to forskolin IEP
IEP: Inferred from expression pattern
21993888 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
19188425 MGI
acts upstream of or within long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
25858512 MGI
acts upstream of or within response to oxygen levels IDA
IDA: Inferred from direct assay
18723672 MGI
acts upstream of or within sensory perception of sound IEP
IEP: Inferred from expression pattern
23646144 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
23185045 MGI
located in synapse IDA
IDA: Inferred from direct assay
23390134 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00464 hsa-miR-221-3p mimic 99.23% Unkown
HY-RI00464 hsa-miR-221-3p inhibitor 99.14% Unkown
HY-R00465 hsa-miR-221-5p mimic 97.50% Unkown
HY-RI00465 hsa-miR-221-5p inhibitor 99.55% Unkown
HY-R02845 mmu-miR-221-5p mimic 93.81% Unkown
HY-RI02845 mmu-miR-221-5p inhibitor 99.53% Unkown
HY-125026 MyomiRs-IN-1 / Unkown
HY-R00464A hsa-miR-221-3p agomir / Unkown
HY-R00465A hsa-miR-221-5p agomir / Unkown
HY-R02845A mmu-miR-221-5p agomir / Unkown
HY-R04311 rno-miR-221-5p mimic / Unkown
HY-R04311A rno-miR-221-5p agomir / Unkown
HY-RI00464A hsa-miR-221-3p antagomir / Unkown
HY-RI00465A hsa-miR-221-5p antagomir / Unkown
HY-RI02845A mmu-miR-221-5p antagomir / Unkown
HY-RI04311 rno-miR-221-5p inhibitor / Unkown
HY-RI04311A rno-miR-221-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir221 NCBI NCBI:407006