2. Gene
  3. Mir34b - microRNA 34b Gene

Mir34b - microRNA 34b Gene

  • Gene
  • Agent
Mus musculus

Also known as Mirn34b; mir-34b; mmu-mir-34b

Gene ID: 723849 | Gene type: ncRNA

About Mir34b

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within embryonic brain development IGI
IGI: Inferred from genetic interaction
24982181 MGI
acts upstream of or within motile cilium assembly IGI
IGI: Inferred from genetic interaction
24982181 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
24982181 MGI
acts upstream of or within negative regulation of gene expression IDA
IDA: Inferred from direct assay
19895913 MGI
acts upstream of or within negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
24982181 MGI
acts upstream of or within ossification IDA
IDA: Inferred from direct assay
25751060 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
24982181 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
24982181 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RI00716 hsa-miR-34b-5p inhibitor 97.99% Unkown
HY-RI00716A hsa-miR-34b-5p antagomir 98.45% Unkown
HY-R00715 hsa-miR-34b-3p mimic / Unkown
HY-R00715A hsa-miR-34b-3p agomir / Unkown
HY-R00716 hsa-miR-34b-5p mimic / Unkown
HY-R00716A hsa-miR-34b-5p agomir / Unkown
HY-RI00715 hsa-miR-34b-3p inhibitor / Unkown
HY-RI00715A hsa-miR-34b-3p antagomir / Unkown