2. Gene
  3. Mir451a - microRNA 451a Gene

Mir451a - microRNA 451a Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Mir451; Mirn451; mir-451a; mmu-mir-451; mmu-mir-451a

Gene ID: 723870 | Gene type: ncRNA

About Mir451a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular hyperosmotic salinity response IDA
IDA: Inferred from direct assay
17028171 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18791161 MGI
involved in erythrocyte differentiation IGI
IGI: Inferred from genetic interaction
30971389 MGI
involved in gene expression IGI
IGI: Inferred from genetic interaction
30971389 MGI
involved in mRNA catabolic process IGI
IGI: Inferred from genetic interaction
30971389 MGI
involved in mRNA destabilization IGI
IGI: Inferred from genetic interaction
30971389 MGI
involved in miRNA-mediated post-transcriptional gene silencing IMP
IMP: Inferred from mutant phenotype
30971389 MGI
involved in mitochondrial ATP synthesis coupled electron transport IMP
IMP: Inferred from mutant phenotype
30971389 MGI
involved in regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
30971389 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within response to wounding IEP
IEP: Inferred from expression pattern
24205035 MGI
acts upstream of or within sensory perception of sound IEP
IEP: Inferred from expression pattern
23646144 MGI
Cellular Component GO Annotation Evidence Reference Source
part of RISC complex IDA
IDA: Inferred from direct assay
7949730 MGI
part of RNAi effector complex IDA
IDA: Inferred from direct assay
30971389 MGI
part of RNAi effector complex IMP
IMP: Inferred from mutant phenotype
30971389 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
24205035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R01139 hsa-miR-451a mimic 97.11% Unkown
HY-RI01139 hsa-miR-451a inhibitor 93.78% Unkown
HY-R01139A hsa-miR-451a agomir / Unkown
HY-RI01139A hsa-miR-451a antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir451a NCBI NCBI:574411