Spink5 - serine peptidase inhibitor, Kazal type 5 Gene

Mus musculus

Also known as LEKT1; LETK1; VAKT1; 2310065D10Rik

Gene ID: 72432 | Gene type: protein coding

About Spink5

Summary

Enables peptidase inhibitor activity. Involved in negative regulation of Antibacterial peptide production and negative regulation of serine-type endopeptidase activity. Acts upstream of or within negative regulation of serine-type peptidase activity and regulation of cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Is expressed in back skin. Used to study Netherton syndrome. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5). [provided by Alliance of Genome Resources, Apr 2022]

Spink5 Products(1)

mRNA	Protein	Name
NM_001081180.1	NP_001074649.1	serine protease inhibitor Kazal-type 5 precursor

Protein Preferred Names

Protein Names

serine protease inhibitor Kazal-type 5

Netherton syndrome

serine protease inhibitor, Kazal type 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13682	SPINK5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spink5	NCBI	NCBI:11005

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