Setd5 - SET domain containing 5 Gene

Also Known as mKIAA1757; C330007C20; 2900045N06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72895

Summary

Enables Histone Methyltransferase activity (H3-K36 specific) and Histone Methyltransferase activity (H3-K9 specific). Involved in several processes, including histone H3-K36 trimethylation; regulation of DNA-templated transcription, elongation; and regulation of histone acetylation. Located in euchromatin and nucleus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 23. Orthologous to human SETD5 (SET domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Setd5 Products (2)

mRNA Protein Name
NM_028385.1 NP_082661.1 histone-lysine N-methyltransferase SETD5 isoform 1
NM_173005.1 NP_766593.1 histone-lysine N-methyltransferase SETD5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables histone H3 methyltransferase activity IDA
IDA: Inferred from direct assay
30455454 MGI
enables histone H3K36 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
31515109 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
22939622 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27864380 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
30455454 MGI
Biological Process GO Annotation Evidence References Source
involved in cognition IMP
IMP: Inferred from mutant phenotype
30455454 MGI
involved in negative regulation of transcription by RNA polymerase III IMP
IMP: Inferred from mutant phenotype
30455454 MGI
involved in regulation of DNA-templated transcription elongation IMP
IMP: Inferred from mutant phenotype
31515109 MGI
involved in regulation of chromatin organization IMP
IMP: Inferred from mutant phenotype
27864380 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
31515109 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
27864380 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
31515109 MGI
located in nucleus IDA
IDA: Inferred from direct assay
27864380 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SETD5

  • SET domain-containing protein 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12745 SETD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setd5 NCBI NCBI:55209