Marchf1 - membrane associated ring-CH-type finger 1 Gene

Also Known as March1; 2900024D24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72925

Summary

Enables ubiquitin protein Ligase activity. Involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Located in bounding membrane of organelle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in central nervous system. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Marchf1 Products (24)

mRNA Protein Name
NM_001166372.2 NP_001159844.1 E3 ubiquitin-protein ligase MARCHF1 isoform 1
NM_001166375.1 NP_001159847.1 E3 ubiquitin-protein ligase MARCHF1 isoform 2
NM_001293784.2 NP_001280713.1 E3 ubiquitin-protein ligase MARCHF1 isoform 4
NM_001363123.2 NP_001350052.1 E3 ubiquitin-protein ligase MARCHF1 isoform 3
NM_001363124.2 NP_001350053.1 E3 ubiquitin-protein ligase MARCHF1 isoform 1
NM_001363125.2 NP_001350054.1 E3 ubiquitin-protein ligase MARCHF1 isoform 5
NM_001403873.1 NP_001390802.1 E3 ubiquitin-protein ligase MARCHF1 isoform 6
NM_001403874.1 NP_001390803.1 E3 ubiquitin-protein ligase MARCHF1 isoform 7
NM_001403875.1 NP_001390804.1 E3 ubiquitin-protein ligase MARCHF1 isoform 7
NM_001403876.1 NP_001390805.1 E3 ubiquitin-protein ligase MARCHF1 isoform 8
NM_001403877.1 NP_001390806.1 E3 ubiquitin-protein ligase MARCHF1 isoform 9
NM_001403878.1 NP_001390807.1 E3 ubiquitin-protein ligase MARCHF1 isoform 10
NM_001403879.1 NP_001390808.1 E3 ubiquitin-protein ligase MARCHF1 isoform 4
NM_001403880.1 NP_001390809.1 E3 ubiquitin-protein ligase MARCHF1 isoform 4
NM_001403881.1 NP_001390810.1 E3 ubiquitin-protein ligase MARCHF1 isoform 4
NM_001403882.1 NP_001390811.1 E3 ubiquitin-protein ligase MARCHF1 isoform 4
NM_001403883.1 NP_001390812.1 E3 ubiquitin-protein ligase MARCHF1 isoform 3
NM_001403884.1 NP_001390813.1 E3 ubiquitin-protein ligase MARCHF1 isoform 3
NM_001403885.1 NP_001390814.1 E3 ubiquitin-protein ligase MARCHF1 isoform 1
NM_001403886.1 NP_001390815.1 E3 ubiquitin-protein ligase MARCHF1 isoform 5
NM_001403887.1 NP_001390816.1 E3 ubiquitin-protein ligase MARCHF1 isoform 5
NM_001403889.1 NP_001390818.1 E3 ubiquitin-protein ligase MARCHF1 isoform 11
NM_001403894.1 NP_001390823.1 E3 ubiquitin-protein ligase MARCHF1 isoform 12
NM_175188.5 NP_780397.2 E3 ubiquitin-protein ligase MARCHF1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17255932 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17255932 MGI
Biological Process GO Annotation Evidence References Source
involved in antigen processing and presentation of peptide antigen via MHC class II IMP
IMP: Inferred from mutant phenotype
17255932 MGI
involved in immune response IDA
IDA: Inferred from direct assay
17255932 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
17255932 MGI
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
19880452 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19880452 MGI
located in late endosome membrane IDA
IDA: Inferred from direct assay
19880452 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
19880452 MGI
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
19880452 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MARCHF1

  • E3 ubiquitin-protein ligase MARCH1

  • MARCH-I

  • RING-type E3 ubiquitin transferase MARCH1

  • RING-type E3 ubiquitin transferase MARCHF1

  • membrane-associated RING finger protein 1

  • membrane-associated RING-CH protein I

  • membrane-associated ring finger (C3HC4) 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08143 MARCHF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Marchf1 NCBI NCBI:55016