Fezf1 - Fez family zinc finger 1 Gene

Also Known as Fez; fez-like; Zfp312-like; 3110069A13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 73191

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell dedifferentiation; nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within nervous system development and positive regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including brain and nose. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 22 with or without anosmia. Orthologous to human FEZF1 (FEZ family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Fezf1 Products (1)

mRNA	Protein	Name
NM_028462.1	NP_082738.1	fez family zinc finger protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20431123	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20431123	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	28245922	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	28245922	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	16540508	MGI
involved in cell dedifferentiation	IGI IGI: Inferred from genetic interaction	20152183	MGI
acts upstream of or within forebrain anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16971467	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16540508	MGI
acts upstream of or within interneuron migration	IMP IMP: Inferred from mutant phenotype	16540508	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20431123	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20431123	MGI
acts upstream of neuron differentiation	IGI IGI: Inferred from genetic interaction	20431123	MGI
acts upstream of or within olfactory bulb development	IMP IMP: Inferred from mutant phenotype	16971467	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20431123	MGI
acts upstream of or within positive regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	20431123	MGI
involved in regulation of neurogenesis	IGI IGI: Inferred from genetic interaction	20152183	MGI
involved in telencephalon development	IMP IMP: Inferred from mutant phenotype	20431123	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fez family zinc finger protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04872	FEZF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fezf1	NCBI	NCBI:389549