Bmper - BMP-binding endothelial regulator Gene

Mus musculus

Also known as Cv2; CV-2; Crim3; 3110056H04Rik

Gene ID: 73230 | Gene type: protein coding

About Bmper

Summary

This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013]

Bmper Products(1)

mRNA	Protein	Name
NM_028472.2	NP_082748.1	BMP-binding endothelial regulator protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12897139	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20807528	MGI
involved in SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	20807528	MGI
acts upstream of or within inner ear development	IDA IDA: Inferred from direct assay	21795542	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	12897139	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	20807528	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	16545622	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	12897139	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

BMP-binding endothelial regulator protein

bone morphogenetic protein-binding endothelial cell precursor-derived regulator

crossveinless-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01545	BMPER Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmper	NCBI	NCBI:168667

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