2. Gene
  3. Nme8 - NME/NM23 family member 8 Gene

Nme8 - NME/NM23 family member 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Txndc3; Sptrx-2; 1700056P15Rik

Gene ID: 73412 | Gene type: protein coding

About Nme8

Summary

Predicted to enable microtubule binding activity. Acts upstream of or within cellular response to Reactive Oxygen Species and flagellated sperm motility. Located in axoneme; sperm cytoplasmic droplet; and sperm principal piece. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8). [provided by Alliance of Genome Resources, Apr 2022]

Nme8 Products(2)

mRNA Protein Name
NM_001167909.1 NP_001161381.1 thioredoxin domain-containing protein 3 isoform 2
NM_181591.3 NP_853622.2 thioredoxin domain-containing protein 3 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to reactive oxygen species IGI
IGI: Inferred from genetic interaction
23707457 MGI
acts upstream of or within flagellated sperm motility IGI
IGI: Inferred from genetic interaction
23707457 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axoneme IDA
IDA: Inferred from direct assay
12909633 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12909633 MGI
located in sperm cytoplasmic droplet IDA
IDA: Inferred from direct assay
12909633 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
12909633 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin domain-containing protein 3

spermatid-specific thioredoxin-2

thioredoxin domain containing 3 (spermatozoa)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09379 NME8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nme8 NCBI NCBI:51314