Ttc21b - tetratricopeptide repeat domain 21B Gene

Also Known as aln; Thm1; mKIAA1992; 2410066K11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 73668

Summary

Enables chromatin binding activity. Acts upstream of or within several processes, including central nervous system development; intraciliary retrograde transport; and regulation of signal transduction. Part of intraciliary transport particle A. Is expressed in central nervous system; embryo ectoderm; limb; and somite. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 4 and nephronophthisis 12. Orthologous to human TTC21B (tetratricopeptide repeat domain 21B). [provided by Alliance of Genome Resources, Apr 2022]

Ttc21b Products (2)

mRNA	Protein	Name
NM_001047604.3	NP_001041069.1	tetratricopeptide repeat protein 21B isoform a
NM_001290669.2	NP_001277598.1	tetratricopeptide repeat protein 21B isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	22079090	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Bergmann glial cell differentiation	IMP IMP: Inferred from mutant phenotype	29615573	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	29615573	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	29615573	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	28291836	MGI
acts upstream of or within forebrain dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	19732765	MGI
acts upstream of or within intraciliary retrograde transport	IMP IMP: Inferred from mutant phenotype	18327258	MGI
acts upstream of or within negative regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	27482817	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	27482817	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27482817	MGI
acts upstream of or within protein localization to non-motile cilium	IMP IMP: Inferred from mutant phenotype	27482817	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	19732765	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	18327258	MGI
acts upstream of or within ventricular system development	IMP IMP: Inferred from mutant phenotype	19732765	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of intraciliary transport particle A	IDA IDA: Inferred from direct assay	20889716	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tetratricopeptide repeat protein 21B	TPR repeat protein 21B intraflagellar transport 139 homolog line 158 tetratricopeptide repeat-containing hedgehog modulator 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15202	TTC21B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ttc21b	NCBI	NCBI:79809