Cplane1 - ciliogenesis and planar polarity effector 1 Gene

Also Known as Hug; Jbts17; b2b012Clo; 2410089E03Rik; 4732468D17Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 73692

Summary

Acts upstream of or within several processes, including animal organ development; embryonic digit morphogenesis; and protein localization to ciliary transition zone. Located in ciliary transition zone. Used to study Joubert syndrome 17. Human ortholog(s) of this gene implicated in Joubert syndrome 17 and Joubert syndrome with orofaciodigital defect. Orthologous to human CPLANE1 (ciliogenesis and planar polarity effector 1). [provided by Alliance of Genome Resources, Apr 2022]

Cplane1 Products (1)

mRNA	Protein	Name
NM_001162906.1	NP_001156378.1	ciliogenesis and planar polarity effector 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27158779	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cardiac septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within establishment of planar polarity	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within protein localization to ciliary transition zone	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	25877302	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25877302	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary transition zone	IDA IDA: Inferred from direct assay	25877302	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ciliogenesis and planar polarity effector 1	protein C5orf42 homolog protein JBTS17 transmembrane protein ENSP00000382582 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03096	CPLANE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cplane1	NCBI	NCBI:65250