Rbm20 - RNA binding motif protein 20 Gene

Mus musculus

Also known as 1110018J23Rik; 2010003H22Rik

Gene ID: 73713 | Gene type: protein coding

About Rbm20

Summary

Enables RNA binding activity. Involved in positive regulation of RNA splicing. Located in nucleus. Is expressed in diaphragm; heart; limb segment; skeletal musculature; and tail paraxial mesenchyme. Used to study atrial fibrillation and dilated cardiomyopathy 1DD. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1DD. Orthologous to human RBM20 (RNA binding motif protein 20). [provided by Alliance of Genome Resources, Apr 2022]

Rbm20 Products(1)

mRNA	Protein	Name
NM_001170847.1	NP_001164318.1	RNA-binding protein 20

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	22466703	MGI
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	32187365	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in heart formation	IMP IMP: Inferred from mutant phenotype	24584570	MGI
involved in negative regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	27630136	MGI
involved in positive regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	22466703	MGI
involved in spliceosome-depend formation of circular RNA	IDA IDA: Inferred from direct assay	37272356	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	35041844	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	23886709	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22466703	MGI
is active in nucleus	IMP IMP: Inferred from mutant phenotype	33110103	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RNA-binding protein 20

probable RNA-binding protein 20

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11739	RBM20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbm20	NCBI	NCBI:282996

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