Ift57 - intraflagellar transport 57 Gene

Also Known as Hippi; MHS4R2; Esrrbl1; 4833420A15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 73916

Summary

Predicted to enable DNA binding activity. Acts upstream of or within several processes, including cilium assembly; epithelial tube morphogenesis; and left/right pattern formation. Located in several cellular components, including cytoskeleton; dendrite terminus; and photoreceptor connecting cilium. Part of intraciliary transport particle B. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; limb bud; and node. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Orthologous to human IFT57 (intraflagellar transport 57). [provided by Alliance of Genome Resources, Apr 2022]

Ift57 Products (1)

mRNA Protein Name
NM_028680.3 NP_082956.2 intraflagellar transport protein 57 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12821668 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
17027958 MGI
acts upstream of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within left/right pattern formation IMP
IMP: Inferred from mutant phenotype
17027958 MGI
acts upstream of or within motile cilium assembly IMP
IMP: Inferred from mutant phenotype
17027958 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
17027958 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
21703454 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17027958 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11788820 MGI
located in axoneme IDA
IDA: Inferred from direct assay
21209331 MGI
located in centrosome IDA
IDA: Inferred from direct assay
19253336 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
17931679 MGI
located in cilium IDA
IDA: Inferred from direct assay
19253336 MGI
located in dendrite terminus IDA
IDA: Inferred from direct assay
20368623 MGI
part of intraciliary transport particle B IDA
IDA: Inferred from direct assay
12821668 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
20368623 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport protein 57 homolog

  • HIP1-interacting protein

  • Vestrogen-related receptor beta like 1

  • estrogen-related receptor beta like 1

  • huntingtin-interacting protein-1 protein interactor

  • intraflagellar transport 57 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06607 IFT57 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ift57 NCBI NCBI:55081