Traf3ip1 - TRAF3 interacting protein 1 Gene

Mus musculus

Also known as MIP-T3; 3930402D05Rik

Gene ID: 74019 | Gene type: protein coding

About Traf3ip1

Summary

Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium and regulation of microtubule Cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Traf3ip1 Products(1)

mRNA	Protein	Name
NM_028718.2	NP_082994.1	TRAF3-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21307337	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cilium assembly	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of defense response to virus	IMP IMP: Inferred from mutant phenotype	22079989	MGI
acts upstream of or within embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of or within embryonic heart tube development	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22079989	MGI
involved in morphogenesis of a polarized epithelium	IMP IMP: Inferred from mutant phenotype	26487268	MGI
acts upstream of or within negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	22079989	MGI
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	22079989	MGI
acts upstream of or within negative regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22079989	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of or within neural tube patterning	IMP IMP: Inferred from mutant phenotype	21945076	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	21945076	MGI
involved in regulation of microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	26487268	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	21945076	MGI
located in centrosome	IDA IDA: Inferred from direct assay	19253336	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	21945076	MGI
located in cilium	IDA IDA: Inferred from direct assay	19253336	MGI
part of intraciliary transport particle B	IDA IDA: Inferred from direct assay	19253336	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TRAF3-interacting protein 1

TNF receptor-associated factor 3 interacting protein 1	intraflagellar transport protein 54 homolog
microtubule-interacting protein associated with TRAF3	microtubule-interacting protein that associates with TRAF3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14970	TRAF3IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Traf3ip1	NCBI	NCBI:26146

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