Traf3ip1 - TRAF3 interacting protein 1 Gene

Also Known as MIP-T3; 3930402D05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74019

Summary

Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium and regulation of microtubule Cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Traf3ip1 Products (1)

mRNA Protein Name
NM_028718.2 NP_082994.1 TRAF3-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21307337 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of defense response to virus IMP
IMP: Inferred from mutant phenotype
22079989 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of or within embryonic heart tube development IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of interferon-beta production IMP
IMP: Inferred from mutant phenotype
22079989 MGI
involved in morphogenesis of a polarized epithelium IMP
IMP: Inferred from mutant phenotype
26487268 MGI
acts upstream of or within negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
22079989 MGI
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
22079989 MGI
acts upstream of or within negative regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
22079989 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of or within neural tube patterning IMP
IMP: Inferred from mutant phenotype
21945076 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
21945076 MGI
involved in regulation of microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
26487268 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
21945076 MGI
located in centrosome IDA
IDA: Inferred from direct assay
19253336 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
21945076 MGI
located in cilium IDA
IDA: Inferred from direct assay
19253336 MGI
part of intraciliary transport particle B IDA
IDA: Inferred from direct assay
19253336 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF3-interacting protein 1

  • TNF receptor-associated factor 3 interacting protein 1

  • intraflagellar transport protein 54 homolog

  • microtubule-interacting protein associated with TRAF3

  • microtubule-interacting protein that associates with TRAF3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14970 TRAF3IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Traf3ip1 NCBI NCBI:26146