Foxp4 - forkhead box P4 Gene

Also Known as mFKHLA; 1200010K03Rik; 2310007G05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74123

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Apr 2022]

Foxp4 Products (5)

mRNA	Protein	Name
NM_001110824.2	NP_001104294.1	forkhead box protein P4 isoform 1
NM_001110825.2	NP_001104295.1	forkhead box protein P4 isoform 2
NM_001403969.1	NP_001390898.1	forkhead box protein P4 isoform 4
NM_001403970.1	NP_001390899.1	forkhead box protein P4 isoform 5
NM_028767.3	NP_083043.2	forkhead box protein P4 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14701752	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14701752	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	14701752	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14701752	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14701752	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14701752	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	15361625	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15361625	MGI
acts upstream of or within lung secretory cell differentiation	IGI IGI: Inferred from genetic interaction	22675208	MGI
acts upstream of or within negative regulation of lung goblet cell differentiation	IGI IGI: Inferred from genetic interaction	22675208	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701752	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701752	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701752	MGI
acts upstream of or within regulation of lung goblet cell differentiation	IGI IGI: Inferred from genetic interaction	22675208	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
forkhead box protein P4	fork head-related protein like A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05076	FOXP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxp4	NCBI	NCBI:116113